U.K. scientists ask to edit human embryo genes
(Reuters) — British scientists have applied for permission to edit the genes of human embryos in a series of experiments aimed at finding out more about the earliest stages of human development. Just months after Chinese scientists caused an international furor by saying they had genetically modified human embryos, Kathy Niakan, a stem cell scientist from London’s Francis Crick Institute, has asked the British government’s fertility regulator for a license to carry out similar experiments. In a statement about her application, which was made to the Human Fertilization & Embryology Authority, Niakan said she had no intention of genetically altering embryos for use in human reproduction, but aimed to deepen scientific understanding of how a healthy human embryo develops. “This knowledge may improve embryo development after in vitro fertilisation (IVF) and might provide better clinical treatments for infertility,” she said in a statement, adding that any donated embryos would be used for research purposes only. Scientists around the world are currently debating the potential future use of new genetic technology known as CRISPR-Cas9, which allows researchers to edit virtually any gene, including in human embryos. While the technology can enable scientists to find and change or replace genetic defects, critics say it also has the potential to create “designer babies” to order. A spokesman for the HFEA noted that British law bans ...
Authors: Zarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani H Abstract While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and de...
Conditions: Mrk Anomaly; Infertility, Female Intervention: Procedure: uterus transplantation surgery and IVF Sponsors: Sahlgrenska University Hospital, Sweden; Saint Joseph University, at Bellevue Medical Centre Recruiting
Condition: Infertility, Male Interventions: Dietary Supplement: Dietary Supplement with L-carnitine (FertilHom); Dietary Supplement: Control Dietary Supplement Sponsor: NATURAmedicatrix Sàrl Not yet recruiting
CONCLUSION: Despite a more frequent presentation with advanced disease, colorectal cancer has a similar prognosis in pregnancy when compared with the general population. Diagnostic interventions and treatment should not be delayed due to the pregnancy but a balance between maternal and foetal wellbeing must always be kept in mind. PMID: 30010511 [PubMed - as supplied by publisher]
[Nairobi News] Two in every 10 couples suffer from infertility, data has shown.
Conclusions: We found no associations of bisphenols and phthalates with fecundability. Preconception folic acid supplementation seems to modify effects of bisphenols and phthalates on fecundability. Folic acid supplements may protect against reduced fecundability among women exposed to these chemicals. Further studies are needed to replicate these findings and investigate potential mechanisms. PMID: 30016447 [PubMed - as supplied by publisher]
CONCLUSION: Trends favoring twice daily dosing are encouraging findings and require further investigation. PMID: 29999292 [PubMed - in process]
CONCLUSION: Expression of gap junction protein correlates with quantity of oocytes retrieved and might be related to pregnancy outcome. This study suggests that lack of connexin43 expression may contribute to poor ovarian response. PMID: 29999282 [PubMed - in process]
CONCLUSION: When selecting REI fellows for interviews, fellowship directors value candidates who have trained at competitive OB/GYN residency programs, who have clinical or basic science research experience, and who have contributed to scientific literature as first author. When subsequently ranking fellowship applicants, however, the most important factors are those found in the interview process, such as identification as a "team player". PMID: 29999279 [PubMed - in process]
Uterine myomas are common benign monoclonal tumors with extremely low potential for malignancy. They are estimated to be present in up to 70% of women of reproductive age , with a higher incidence in obese women and those of African American descent, and when symptomatic, a frequent indication for gynecologic surgery. Although the presence of myomas may be associated with a plethora of symptoms including pelvic pain, abnormal uterine bleeding, infertility/subfertility, and adverse pregnancy outcomes , the vast majority of women with uterine fibroids are asymptomatic.