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U.K. scientists ask to edit human embryo genes

(Reuters) — British scientists have applied for permission to edit the genes of human embryos in a series of experiments aimed at finding out more about the earliest stages of human development. Just months after Chinese scientists caused an international furor by saying they had genetically modified human embryos, Kathy Niakan, a stem cell scientist from London’s Francis Crick Institute, has asked the British government’s fertility regulator for a license to carry out similar experiments. In a statement about her application, which was made to the Human Fertilization & Embryology Authority, Niakan said she had no intention of genetically altering embryos for use in human reproduction, but aimed to deepen scientific understanding of how a healthy human embryo develops. “This knowledge may improve embryo development after in vitro fertilisation (IVF) and might provide better clinical treatments for infertility,” she said in a statement, adding that any donated embryos would be used for research purposes only. Scientists around the world are currently debating the potential future use of new genetic technology known as CRISPR-Cas9, which allows researchers to edit virtually any gene, including in human embryos. While the technology can enable scientists to find and change or replace genetic defects, critics say it also has the potential to create “designer babies” to order. A spokesman for the HFEA noted that British law bans ...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Business/Financial News Genetic Engineering Source Type: news

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Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Conclusion: WS was found to enhance spermatogenesis and sperm related indices in male and sexual behaviors in female. But, according to some available evidences for spermicidal features, further studies should focus on the extract preparation method and also dosage used in their study protocols. PMID: 29670898 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive research...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
A top question underlying clinical research is, “How can we do better?” One of the easiest opportunities for advancing reproductive endocrinology and infertility (REI) is to take familiar procedures and slightly modify them in order to provide more efficient or effective care than previously achieved. Managing cervical ectopic pregnancy with methotrexate and potassium chloride through technique parallel to follicular aspiration allows safer and more effective treatment than with dilation and curettage or systemic methotrexate.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Conditions:   Embryonic Mosaicism;   Embryo Culture Media;   Embryo Morphokinetics;   Infertility Interventions:   Device: EmbryoScope Plus;   Other: GLOBAL MEDIA;   Other: SAGE MEDIA Sponsor:   University of California, San Francisco Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility Due to Nonimplantation;   Infertility Intervention:   Drug: Prometrium Sponsor:   Mount Sinai Hospital, Canada Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Embryonic Mosaicism;   Embryo Culture Media;   Embryo Morphokinetics;   Infertility Interventions:   Device: EmbryoScope Plus;   Other: GLOBAL MEDIA;   Other: SAGE MEDIA Sponsor:   University of California, San Francisco Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility Due to Nonimplantation;   Infertility Intervention:   Drug: Prometrium Sponsor:   Mount Sinai Hospital, Canada Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Embryonic Mosaicism;   Embryo Culture Media;   Embryo Morphokinetics;   Infertility Interventions:   Device: EmbryoScope Plus;   Other: GLOBAL MEDIA;   Other: SAGE MEDIA Sponsor:   University of California, San Francisco Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility Due to Nonimplantation;   Infertility Intervention:   Drug: Prometrium Sponsor:   Mount Sinai Hospital, Canada Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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