Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally-infected turkeys showing evidence of pancreatic regeneration.

Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally-infected turkeys showing evidence of pancreatic regeneration. Avian Pathol. 2015 Sep 12;:1-35 Authors: Cavicchioli L, Zappulli V, Beffagna G, Caliari D, Zanetti R, Nordio L, Mainenti M, Frezza F, Bonfante F, Patrono LV, Capua I, Terregino C Abstract In order to investigate the pancreatic lesions caused by the infection with either H7N1 or H7N3 low-pathogenicity avian influenza (LPAI) viruses, 28 experimentally-infected turkeys were submitted for histopathology, immunohistochemistry, hematobiochemistry and RRT-PCR after different days post-infection (DPI). The localization of viral antigen and the measurement of insulin and glucagon expression in the pancreas were assessed to verify the progression from pancreatitis to metabolic disorders, such as diabetes. PMID: 26365055 [PubMed - as supplied by publisher]
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

Related Links:

Publication date: Available online 12 November 2019Source: Veterinary MicrobiologyAuthor(s): Sahar Rostami, Jalil Mehrzad, Ramak Yahyaraeyat, Taghi Zahraei SalehiAbstractSalmonella enterica Subsp enterica serovar Typhimurium (S. Typhimurium, ST) is one of the most important serovars of the genus Salmonella in human and animals. Because of its intracellular tropism, monocytes/macrophages are pivotal in killing of Salmonella serovars; they are also responsible for transporting of ST to extra-intestinal organs. To investigate the effect of the ST on the functions of avian innate immune cells, almost homogeneous enriched monoc...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Authors: Fukaishi T, Minami I, Masuda S, Miyachi Y, Tsujimoto K, Izumiyama H, Hashimoto K, Yoshida M, Takahashi S, Kashimada K, Morio T, Kosaki K, Maezawa Y, Yokote K, Yoshimoto T, Yamada T Abstract We herein report a case of a 28-year-old man with generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement. He showed symptoms of generalized lipodystrophy around onset of puberty. His body mass index was 11.9 kg/m2, and he had a short stature, birdlike facies, dental crowding due to micrognathia, partial graying and loss of hair, and a high-pitched voice, all of which are typical features o...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
High blood pressure? There ’s an app for that. Diabetes? There’s an app for that, too. Want to quit smoking? Keep track of your exercise? Is your anxiety getting the better of you? There are apps for all of those health issues, hundreds of thousands of apps. Developers at Blue Shield of California have rolled out a ne w, enhanced Wellvolution website — Wellvolution Next — that brings together roughly 40 of the best “digital therapeutics” applications in one place where members can…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Eman Soliman, Shereen F. Behairy, Nabila N. El-maraghy, Shimaa M. ElshazlyAbstractPeroxisome proliferator-activated receptor γ (PPAR-γ) agonist, pioglitazone, is used clinically to improve the glycemic state in patients with type-2 diabetes mellitus. Independent of its blood glucose-lowering properties, pioglitazone ameliorates different cardiovascular disorders. The aim of the present study was to investigate the effect of pioglitazone on cardiovascular complications of N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensi...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Hauwa’u Yakubu Bako, Mohammed Auwal Ibrahim, Muhammad Sani Isah, Sani IbrahimAbstractAimsChronic inflammation is associated with the production of high levels of proinflammatory cytokines via the JAK-STAT and NF-κB signalling pathways which are known to be inhibited by tofacitinib and aspirin respectively. High levels of these cytokines increase the synthesis of suppressors of cytokines (SOCS), which at high levels inhibit insulin signalling leading to insulin resistance. The effects of tofacitinib and aspirin on the degree of in...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Younis Ahmad Hajam, Seema RaiAbstractAimsThe present study was designed to ameliorate the integrated efficacy of exogenous melatonin and insulin on tissue biochemical, serological, histopathological architecture and receptor expression of melatonin (MT1, MT2) and insulin receptor (IR) expression against the hepatic injury in diabetic rats. Materials and Method; the rats were randomly allocated into nine different experimental groups. Diabetes was induced by streptozotocin (15mg/kg) for 6 days. Rats having blood glucose level above 250mg/dl w...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 12 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Luisa Paizoni, Matthias K. Auer, Heinrich Schmidt, Angela Hübner, Martin Bidlingmaier, Nicole ReischAbstractData on cardiovascular morbidity in adults with congenital adrenal hyperplasia (CAH) is sparse. We therefore aimed to determine the role of androgen control and glucocorticoid therapy on metabolic health. For that purpose, we included 90 patients (N = 39 men, N = 51 women) with classic CAH due to 21-hydroxylase deficiency (N = 61 salt wasting, N&...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 13 November 2019Source: PeptidesAuthor(s): Nigel Irwin, Victor A. Gault, Finbarr P.M. O’Harte, Peter R. FlattAbstractGastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes and promotion of fat deposition in tissues. As such, blockade of GIP receptor (GIPR) action has been proposed as a means to counter insulin resistance, and...
Source: Peptides - Category: Biochemistry Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Ragip Pala, Mehmet Akif Sari, Fusun Erten, Besir Er, Mehmet Tuzcu, Cemal Orhan, Patrick Brice Defo Deeh, Nurhan Sahin, Vedat Cinar, James R. Komorowski, Kazim SahinABSTRACTBackgroundChromium picolinate (CrPic) is commonly used to reduce muscle fatigue after exercise. We aimed to elucidate the effects of CrPic on glucose and lipid metabolism and the expression of glucose transporters in exercised rats.MethodsForty-two male Wistar rats (8-week-old) were distributed into six groups (n = 7) as fo...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Overly expensive insulin could be a thing of the past – and life-changing news – for millions of diabetics under a plan launched by the World Health Organization (WHO) on Wednesday to diversify production globally, just ahead of World Diabetes Day.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
More News: Bird Flu | Diabetes | Endocrinology | Influenza | Insulin | Pancreas | Pancreatitis | Pathology | Study