Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally-infected turkeys showing evidence of pancreatic regeneration.

Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally-infected turkeys showing evidence of pancreatic regeneration.
Avian Pathol. 2015 Sep 12;:1-35
Authors: Cavicchioli L, Zappulli V, Beffagna G, Caliari D, Zanetti R, Nordio L, Mainenti M, Frezza F, Bonfante F, Patrono LV, Capua I, Terregino C
Abstract
In order to investigate the pancreatic lesions caused by the infection with either H7N1 or H7N3 low-pathogenicity avian influenza (LPAI) viruses, 28 experimentally-infected turkeys were submitted for histopathology, immunohistochemistry, hematobiochemistry and RRT-PCR after different days post-infection (DPI). The localization of viral antigen and the measurement of insulin and glucagon expression in the pancreas were assessed to verify the progression from pancreatitis to metabolic disorders, such as diabetes.
PMID: 26365055 [PubMed - as supplied by publisher]

Source: Avian Pathology - September 12, 2015 Category: Pathology Authors: Cavicchioli L, Zappulli V, Beffagna G, Caliari D, Zanetti R, Nordio L, Mainenti M, Frezza F, Bonfante F, Patrono LV, Capua I, Terregino C Tags: Avian Pathol Source Type: research