Cancer Risk Elevated With Glyburide Over Other Sulfonylureas Cancer Risk Elevated With Glyburide Over Other Sulfonylureas
Overall cancer risk with glyburide was not significantly elevated, but significant dose- and duration-response relationships were seen with glyburide and breast, prostate, and colorectal cancers. Medscape Medical News
Authors: Popa A, Georgescu M, Popa SG, Nica AE, Georgescu EF Abstract Steadily, cancer is becoming the first cause of mortality, with over 9 million deaths estimated in 2018. Increasing evidence supports a direct association between obesity, type 2 diabetes mellitus (T2DM) and cancer, with a higher risk of cancer mortality especially for some of the most common malignancies, such as breast, colon, and rectal cancers. So far, several mechanisms underlying the cancer-diabetes relationship have been investigated revealing dysregulations of the insulin-insulin-like growth factor (IGF) system as the most important parad...
ConclusionsInsulin ‐induced oxaliplatin resistance was reversed by metformin‐mediated AMPK activation. Accordingly, metformin is likely to sensitize patients with diabetes to chemotherapeutic drugs used to treat colon cancer.
This study highlights the potential of ASA/MET treatments to modulate CRC spreading. PMID: 32247264 [PubMed - as supplied by publisher]
Novel findings of this study include: the genetically predicted expressions of FOXA1, PSMC5 and CD33 modified the association of BMI on CRC risk for men; KIAA0753 and SCN1B modified the association of BMI on CRC risk for women; and PTPN2 modified the association between diabetes and CRC risk in both sexes. These findings provide support for potential new biological insights that could help in understanding the underlying mechanisms of BMI and diabetes on CRC. AbstractBackgroundBody mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. ...
Conclusions: Compared to conventional thrombocytosis, as an individual metric, PIT values may indicate the condition of patients more precisely. Possible future applications of PIT may include its usage in therapy decision and early cancer detection; therefore, further investigations are recommended.
Authors: Shiroma PR, Velasquez T, Usset TJ, Wilhelm JH, Thuras P, Baltutis E Abstract INTRODUCTION: Obesity is prevalent among users of Veteran's Health Administration services, where it is comorbid with depression, post-traumatic stress disorder, type 2 diabetes, cardiovascular disease, colon, and breast cancer. Among obese subjects, severe obesity represents a subpopulation with the highest risk of depression. We investigate the antidepressant effect of a local VA weight management program (Managing Overweight Veterans Everywhere - MOVE) among depressed veterans with severe obesity. MATERIAL AND METHODS: In a...
CONCLUSION: GDM is associated with a greater risk of cancer in women, including breast, thyroid, stomach and liver cancers. However, further investigation is nonetheless warranted. PMID: 32097717 [PubMed - as supplied by publisher]
ConclusionOur study provides information about comorbidities in cancer patients being treated by office-based physicians in an ambulatory setting.
Conclusions: Diabetes increased the risk of all-cause mortality among breast, prostate, and colorectal cancer survivors, not for pre- or post-diagnosis diabetes. Greater attention on diabetes management is warranted in cancer survivors with diabetes.
This article reviews the composition and function of the healthy human GI microbiome, including the relative abundances of different bacterial taxa and the specific metabolic pathways and classes of microbial metabolites contributing to human health and disease prevention.