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Cancer treatment outcomes are influenced by genetics and race, according to new study

A person's response to anticancer drug treatments is strongly related to their genetic ancestry, new research concludes. Notable associations were found for the drug temozolomide, which is used to treat brain tumors. Other drugs with results that suggest an association include etoposide and mitomycin, but the authors note that these results should be viewed as hypothesis generation.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSION: Childhood cancer survivors are at considerable risk of unemployment in adulthood. They may benefit from psycho-social care services along the cancer trajectory to support labor market integration. PMID: 29229046 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Publication date: Available online 13 December 2017 Source:Molecular Aspects of Medicine Author(s): Claudia Quezada, Ángelo Torres, Ignacio Niechi, Daniel Uribe, Susana Contreras-Duarte, Fernando Toledo, Rody San Martín, Jaime Gutiérrez, Luis Sobrevia The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their b...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
This study aims to determine if there is a seasonal variation in cancer diagnoses in the pediatric population at the IWK Health Centre, a tertiary care center serving three Canadian provinces: Nova Scotia, New Brunswick, and Prince Edward Island. All pediatric cancer patients aged 0 –20 y diagnosed from 1995 to 2015 at the center were included in this study. The annual data was divided into four seasonal periods (December to February, March to May, June to August, and September to November). The cancer diagnoses were categorized as leukemia, lymphoma, sarcoma, brain tumors, and miscellaneous. Seasonal variation ...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Publication date: Available online 21 November 2017 Source:Seminars in Cancer Biology Author(s): Olga Gusyatiner, Monika E. Hegi Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the most malignant form (WHO grade IV), and notorious for treatment resistance. Over the last decade mutations in epigenetic regulator genes have been identified as key drivers of subtypes of gliomas with distinct clinical features. Most characteristic are mutations in IDH1 or IDH2 in lower grade gliomas, and histone 3 mutations in pediatric high grade gliomas that are also associated with characteristic DNA met...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Condition:   Advanced Cancer Intervention:   Drug: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine Sponsor:   DEKK-TEC, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion.Comprehensive genomic profiling of pediatric gliomas provides objective data that promote diagnostic accuracy and enhance clinical decision‐making. Additionally, TMB could be a biomarker to identify pediatric glioblastoma (GBM) patients who may benefit from immunotherapy.Implications for Practice.By providing objective data to support diagnostic, prognostic, and therapeutic decision‐making, comprehensive genomic profiling is necessary for advancing care for pediatric neuro‐oncology patients. This article presents the largest cohort of pediatric low‐ and high‐grade gliomas profiled by next‐generation ...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Neuro-Oncology, Precision Medicine ‐ Source Type: research
Conclusion: Awareness of this tumor is important as it portends a poor outcome in most patients, in spite of multi-modal treatment. Several new molecules which aim to prolong survival and improve quality of life are being developed to combat this enigmatic tumor.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: Our study suggests that WWP2 may play a role in the genesis and development of glioma; it may be a potential biomarker to predict pathological grade and tumor recurrence in patients with glioma.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: The results of this study propose a healthy diet such as high intake of vitamins C and E, calcium, fiber, food groups like fruits and vegetables, and low-fat milk and nuts; and low consumption of total fat, SFA, and red meat may be protective against glioma. PMID: 29236551 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
In this experimental and computational study, three biophysical models are developed and evaluated for their ability to accurately describe in vivo growth and response following whole brain radiotherapy. Models that include reduced proliferation post-radiotherapy more accurately predicted future tumor growth.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Biology Contribution Source Type: research
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