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Cancer treatment outcomes are influenced by genetics and race, according to new study

A person's response to anticancer drug treatments is strongly related to their genetic ancestry, new research concludes. Notable associations were found for the drug temozolomide, which is used to treat brain tumors. Other drugs with results that suggest an association include etoposide and mitomycin, but the authors note that these results should be viewed as hypothesis generation.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Source: Cancer Nursing - Category: Nursing Tags: DEPARTMENTS: Cochrane Nursing Summary Source Type: research
Conclusion: 18F-FB-endostatin shows promising in-vivo properties. Therefore, the promising properties of 18F-FB-endostatin indicate that this probe can be a powerful tool to evaluate the antiangiogenic therapy for gliomas and thus warrants further investigation as a novel PET probe for imaging of tumor angiogenesis.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Publication date: Available online 20 October 2017 Source:Trends in Pharmacological Sciences Author(s): Vinod Kumar, Virender Kumar, Timothy McGuire, Donald W. Coulter, John G. Sharp, Ram I. Mahato Medulloblastoma (MB) is the most common childhood brain tumor, which occurs in the posterior fossa. MB tumors are highly heterogeneous and have diverse genetic make-ups, with differential microRNA (miRNA) expression profiles and variable prognoses. MB can be classified into four subgroups, each with different origins, pathogenesis, and potential therapeutic targets. miRNA and small-molecule targeted therapies have emerged as a ...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Authors: Wu Y, Liang S, Xu B, Zhang R, Zhu M, Zhou W, Zhang S, Guo J, Xu L, Zhu H Abstract Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. Recent advances have implicated long noncoding RNAs (lncRNAs) as crucial mediators of cancer development and progression. The present study aimed to investigate the role of a newly-discovered lncRNA, termed eosinophil granule ontogeny transcript (EGOT), in the aggressive abilities of cells in human glioma. It was initially found that the relative transcription level of EGOT in glioma cancerous tissues was ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
The passing of singer-songwriter Gord Downie also puts a spotlight on the need for more funding for research into the form of brain cancer that about 1,000 Canadians are diagnosed with every year.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
Authors: Babic I, Nurmemmedov E, Yenugonda VM, Juarez T, Nomura N, Pingle SC, Glassy MC, Kesari S Abstract Immunotherapy is now at the forefront of cancer therapeutic development. Gliomas are a particularly aggressive form of brain cancer for which immunotherapy may hold promise. Pritumumab (also known in the literature as CLNH11, CLN-IgG, and ACA-11) was the first monoclonal antibody tested in cancer patients. Pritumumab is a natural human monoclonal antibody developed from a B lymphocyte isolated from a regional draining lymph node of a patient with cervical carcinoma. The antibody binds ecto-domain vimentin on t...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
Abstract Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age‐dependent heterogeneity. Herein, we summarize the current state of the AYA population in neuro‐oncology, specificall...
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: AYA ONCOLOGY: REVIEW Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
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