Resveratrol impacts Alzheimer's disease biomarker

The largest nationwide clinical trial to study high-dose resveratrol long-term in people with mild to moderate Alzheimer's disease found that a biomarker that declines when the disease progresses was stabilized in people who took the purified form of resveratrol. Resveratrol is a naturally occurring compound found in foods such as red grapes, raspberries, dark chocolate and some red wines.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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In this study, we investigated the potential effects of disocin on amyloid-β peptide (Aβ1-42) oligomers-treated HT22 cells. Aβ1-42 oligomers induced great neurotoxicity to HT22 cells as examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of terminal deoxynucleoitidyl transferase-mediated deoxyuridine triphosphate biotin nich end labeling (TUNEL) staining and flow cytometry indicated that Aβ1-42 oligomers led to increased apoptosis and generation of reactive oxygen species (ROS) in HT22 cells. However, dioscin could remarkably inhibit the neurotoxicity induce...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
This study is preliminary but findings are interesting, which is a first step to provide quantifiable evidences to measure sleep as a risk factor of AD. PMID: 32308848 [PubMed - indexed for MEDLINE]
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research
Authors: PMID: 32743933 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
CONCLUSION: Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes. PMID: 32743902 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 3 August 2020Source: Life Sciences in Space ResearchAuthor(s): Laura Owlett, Elizabeth K. Belcher, Dawling A. Dionisio-Santos, Jacqueline P. Williams, John A. Olschowka, M. Kerry O'Banion
Source: Life Sciences in Space Research - Category: Biology Source Type: research
PSCI shows a high incidence on acute stage, and more than a half (54.4%) of patients suffered with PSCI. Reduced serum thiamine was associated with early cognitive impairment in patients with acute infarction after adjusting for potential confounding factors. Advanced age, lower education, diabetes mellitus, left hemisphere infarction, and higher NIHSS were also independent risk factors for PSCI. AbstractObjectiveReduced thiamine (vitamin B1) had been reported to be associated with cognitive impairment caused by Alzheimer disease. Our study is to explore the association between thiamine and cognitive impairment after acute...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Photo credit Behard Grossgasteiger Hiring in-home care for my neighbor, Joe, was quite an ordeal. The company we chose and their caregivers were great, but the quality of care wasn't the issue. The problem was that Joe resented anyone but me helping him. He locked one caregiver out of his home, let another in but was rude to her, and thoroughly enjoyed one young man, but only because they could discuss golf together. Families hire home care to provide respite and quality care for seniors, but what is a caregiver to do when their loved one refuses to cooperate with this new addition to their care plan? Continue re...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Today's open access paper outlines an investigation into how the aging of hematopoietic stem cell populations in bone marrow, responsible for producing blood and immune cells, can contribute to age-related dysfunction in the brain. The authors find that detrimental effects are mediated by circulating levels of CyPA, a signaling factor that is a part of the senescence-associated secretory phenotype (SASP), an inflammatory mix of signal molecules produced by senescent cells. The focus here is on direct inhibition of CyPA as an approach to therapy, but senolytic treatments to clear senescent cells may be the more useful appro...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Association seen between negative thinking, cognitive decline, neuroimaging markers
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Geriatrics, Internal Medicine, Neurology, Psychiatry, Journal, Source Type: news
Drs Ronald Petersen and John Morris discuss the effects of COVID-19 on Alzheimer's research and drug trials.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news
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