Human parechovirus infections and child myositis cases associated with genotype 3 in Osaka City, Japan, 2014.

Human parechovirus infections and child myositis cases associated with genotype 3 in Osaka City, Japan, 2014. J Med Microbiol. 2015 Sep 9; Authors: Yamamoto SP, Kaida A, Naito T, Hosaka T, Miyazato Y, Sumimoto SI, Kohdera U, Ono A, Kubo H, Iritani N Abstract Human parechovirus (HPeV) infects humans early in life and typically causes asymptomatic or mild diseases such as gastrointestinal and respiratory illness, but sometimes leads to more serious consequences in neonates and young infants. In 2014, we detected HPeV from 38 patients by real-time RT-PCR in Osaka City, Japan, and 33 HPeV strains were genotyped based on their VP1 sequences. HPeV genotype 3 (HPeV-3) was the most prevalent and accounted for 22 cases (66.7%) followed by 9 HPeV-1 (27.3%), 1 HPeV-2 (3.0%), and 1 HPeV-4 (3.0%). Phylogenetic analysis revealed that detected HPeV-3 strains were divided into 3 genetically distinct groups. One was characterized by a novel single amino acid deletion mutation at the N-terminus of the 2A protein as well as the VP1 sequence, whereas the others were closely related to HPeV-3 strains detected in Japan in either 2008 or 2011. These HPeV-3 groups were detected from patients with various symptoms including 3 myositis cases. Recent papers have demonstrated that HPeV-3 was the etiological agent for epidemic myalgia exclusively among adults from Yamagata prefecture in Japan. Here we provide clinical details and episodes of three myositis patie...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research