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Osteomyelitis of the Mandible in an Adolescent

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Source Type: research

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Staphylococcus aureus wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of S. aureus skin infection, antibody neutralization of α-toxin (AT), a S. aureus secreted pore-forming cytolytic toxin, reduces disease severity by inhibiting skin necrosis and restoring effective host immune responses. However, whether therapeutic neutralization of α-toxin is effective against S. aureus-infected wounds is unclear.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
CONCLUSIONS: The use of BAG-S53P4 in patients with COM and infected non-unions is promising. Adequate debridement and proper defect filling are necessary. BAG is well tolerated. X-ray examinations showed a thickened neo-cortex. The antibacterial effect is not mediated by antibiotics and is advantageous in times of evolving antibiotic resistance. High quality studies with a longer follow-up are required. TRIAL REGISTRATION: TRN DRKS00011679. PMID: 29665602 [PubMed - in process]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Semin Musculoskelet Radiol 2018; 22: 147-165 DOI: 10.1055/s-0038-1639468We discuss the imaging of several juvenile inflammatory arthropathies including juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile scleroderma, juvenile dermatomyositis, and chronic recurrent multifocal osteomyelitis. Juvenile idiopathic arthritis is the most common autoimmune chronic systemic disease of connective tissue in children. The remaining systemic juvenile connective tissue diseases are rare. However, they require early diagnosis and initiation of treatment to prevent injury, not only to the musculoskeletal system ...
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
This article provides an overview of the radiologic appearances of SAPHO/CRMO and relevant pathogenetic, clinical, and pathologic features to facilitate the diagnosis that often requires an interdisciplinary approach including radiologists. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
ConclusionDensely sclerotic bone lesions are amenable to percutaneous needle biopsy.
Source: Skeletal Radiology - Category: Radiology Source Type: research
Focus:
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
The recent paper by Goldblatt et  al. 1 attempts to resurrect an orofacial pain concept that has come and gone several times in the past 30-40 years. As they correctly point out in their first paragraph, this concept has had many different names in the past (ischemic osteonecrosis, bone marrow edema syndrome, neuralgia-inducing ca vitational osteonecrosis (NICO), Ratner bone cavity, and alveolar cavitational osteopathosis). Now these authors have presented similar findings under the new name of chronic fibrosing osteomyelitis of the jaws (CFOJ), but clearly they are still invoking a familiar theory that they believe c...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Miscellaneous Source Type: research
Authors: Boles LR, Awais R, Beenken KE, Smeltzer MS, Haggard WO, Jessica AJ Abstract Military personnel have high risk for infection, particularly those with combat-related extremity trauma. Administration of multiple or broad-spectrum antibiotics provides clinicians with a strategy for preventing biofilm-based medical device infections. Selection of effective antibiotic combinations based on common pathogens may be used to improve chitosan wound dressing sponge-based local antibiotic delivery systems. In vitro assays in this study demonstrate that vancomycin and amikacin have a synergistic relationship against a s...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Wells CM, Beenken KE, Smeltzer MS, Courtney HS, Jennings JA, Haggard WO Abstract Complex extremity wounds in Wounded Warriors can become contaminated with microbes, which may cause clinical outcomes resulting in amputation, morbidity, or even fatality. Local delivery of multiple or broad-spectrum antibiotics allows practicing clinicians treatment solutions that may inhibit biofilm formation. Propagation of vancomycin-resistant Staphylococcus aureus is also a growing concern. The development of vancomycin-resistant S. aureus has become a critical challenge in nosocomial infection prevention in the USA, but ...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Publication date: Available online 14 April 2018 Source:Fuß & Sprunggelenk Author(s): Rebecca Hartmann, Stephan Wirth Bei Patienten mit Diabetes mellitus kommt es aufgrund einer vorliegenden Polyneuropathie sowie Makro- und Mikrozirkulationsstörungen gehäuft zu Fussulzerationen. Werden diese Ulcera nicht früh genug mittels guter Wundpflege konservativ behandelt, kann es zu Infektionen bis hin zu einer Osteomyelitis kommen. Oft liegt den chronischen Ulzerationen aber auch eine ossäre Fehlstellung des Fusses zugrunde. Dann ist es möglich, dass trotz guter Wundpflege die Ulzerationen nicht ...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
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