Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX2 Active Site, and Implications for Endocrine Disruption

Conclusions: Chemicals with structural features more varied than previously thought suppress PGD2 synthesis. Our findings signal a need for in-vivo studies to establish the extent of endocrine disrupting effects that might arise from interference with PGD2 signalling and androgen action simultaneously.

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Citation: Kugathas S, Audouze K, Ermler S, Orton F, Rosivatz E, Scholze M, Kortenkamp A. Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX2 Active Site, and Implications for Endocrine Disruption. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409544.
Received: 1 December 2014
Accepted: 4 September 2015
Advance Publication: 11 September 2015
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Source: EHP Research - September 11, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research