J. Silvio Gutkind

Associate Director, Basic ScienceJ. Silvio Gutkind received his Ph.D. in Pharmacy and Biochemistry from the University of Buenos Aires, Argentina. He was trained as a post-doctoral fellow at the NIMH and NCI, and joined the National Institute of Dental and Craniofacial Research (NIDCR), NIH, where he is currently the Chief of the Oral and Pharyngeal Cancer Branch. Dr. Gutkind is a national and international leader in the study of basic signal transduction mechanisms in cancer. He is recognized for his pioneering research aimed at unraveling the complexity of the intracellular signaling circuitry by which cell surface receptors and Rho GTPases control the nuclear expression of growth promoting genes, thereby promoting normal and malignant growth. His recent studies have addressed the role of mutant G proteins and G protein coupled receptors in cancer initiation, with emphasis on ocular melanoma, colon and skin cancer, and AIDS-malignancies. His multidisciplinary team has also made outstanding contributions to the study of the aberrant signaling circuitries driving head and neck cancer progression, including the seminal finding that most head and neck cancer lesions display persistent activation of the PI3K–AKT–mTOR pathway. His team is now exploiting the emerging information for the development of novel mechanism-based anti-cancer therapies. In particular, Dr. Gutkind is currently leading a multi-institutional effort aimed at exploring the clinical benefits of trea...
Source: PHRMA - Category: Pharmaceuticals Authors: Source Type: news

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Conclusion: health is a priceless asset for the group studied. The social representations of quality of life are based on the adoption of health care related to self-care and, in particular, to health promotion actions.
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
Authors: Villena-Suarez JR, Vicente W, Taxa L, Cuéllar L, Nuñez-Butrón MT, Villegas V, Castillo M, Castañeda CA Abstract Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) wit...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
CONCLUSIONS. : Neoadjuvant therapy with dose-dense carboplatin and paclitaxel achieved an elevated frequency of optimal cytoreduction. The post-surgery levels of carcinoembryonic antigen 125 and optimal cytoreduction were independent factors of progression-free survival and overall survival. PMID: 29924276 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
CONCLUSIONS: . The barriers identified for the quality of the information in the selected information systems in health facilities in the Amazon region reflect a multidimensional problem, so strategies for improvement in the subject should be considered. PMID: 29924273 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Researchers from the Fred Hutchinson Cancer Research Center, Washington, found that unprocessed meats, such as steak, are more strongly linked to the condition than bacon.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A new  studyhas found that false positive breast cancer biopsies are costing healthcare facilities over $2.1 billion annually. This high false positive rate and the consequential expenses highlight the need for improved breast cancer diagnostic protocols and technology.Researchers from IBM Watson Health and Seno Medical looked at health care claims filed between 2011 and 2015 from 875,000 women to understand the rate of follow-up procedures after mammography and breast exams. They found that between 2012 and 2015, 8,732,909 patients received diagnostic mammograms, 6,987,399 underwent breast ultrasounds, and 1,585,856 ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Researchers recently published a study on attitudes to longevity that is reminiscent of the 2013 Pew survey. When asked, people want to live a little longer than their neighbors, at the high end of the normal life span for old individuals today. When asked how long they want to live given the guarantee of perfect health, people pick a number close to the maximum recorded human life span. This sounds like a collusion between the instinctive desires for first conformity and secondly hierarchy, deeply entwined with the human condition, present in all of our primate cousins, a self-sabotaging gift from our evolutionary heritag...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
Researchers from the Institute of Cancer Research, London, found that carrying too little weight between the ages of 18 and 24 is particularly risky. Women should not deliberately gain weight.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Former Puma Biotechnology executive, Robert Gadimian, was sentenced to prison for illegally trading on inside information about a breast cancer drug.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Conclusion: The chloroform fraction from the 95% ethanolic extract of dried leaves was the most effective fraction against bile duct and colon cancer cell lines, thus this extract should be further investigated for active compounds possessing those observed cytotoxic activity. PMID: 29919996 [PubMed]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: General Medicine Tags: J Med Assoc Thai Source Type: research
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