J. Silvio Gutkind

Associate Director, Basic ScienceJ. Silvio Gutkind received his Ph.D. in Pharmacy and Biochemistry from the University of Buenos Aires, Argentina. He was trained as a post-doctoral fellow at the NIMH and NCI, and joined the National Institute of Dental and Craniofacial Research (NIDCR), NIH, where he is currently the Chief of the Oral and Pharyngeal Cancer Branch. Dr. Gutkind is a national and international leader in the study of basic signal transduction mechanisms in cancer. He is recognized for his pioneering research aimed at unraveling the complexity of the intracellular signaling circuitry by which cell surface receptors and Rho GTPases control the nuclear expression of growth promoting genes, thereby promoting normal and malignant growth. His recent studies have addressed the role of mutant G proteins and G protein coupled receptors in cancer initiation, with emphasis on ocular melanoma, colon and skin cancer, and AIDS-malignancies. His multidisciplinary team has also made outstanding contributions to the study of the aberrant signaling circuitries driving head and neck cancer progression, including the seminal finding that most head and neck cancer lesions display persistent activation of the PI3K–AKT–mTOR pathway. His team is now exploiting the emerging information for the development of novel mechanism-based anti-cancer therapies. In particular, Dr. Gutkind is currently leading a multi-institutional effort aimed at exploring the clinical benefits of trea...
Source: PHRMA - Category: Pharmaceuticals Authors: Source Type: news

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ConclusionThere is a paucity of treatment guidelines for acute lung injury secondary to marijuana inhalation. We advocate early use of short-term steroids and also more awareness on quitting marijuana smoking to prevent life-threatening complications like myocardial infarction, diffuse alveolar hemorrhage and acute respiratory distress syndrome.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Conclusions: MPE is common at presentation (11%) in patients with SCLC and may be associated with decreased survival. Additional studies are required to assess the treatment-adjusted survival rate in the setting of MPE.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Conclusions: pGTV, as a measure of tumor size, is not only an important prognostic indicator but also an independent predictive factor of tumor response, even pCR. PMID: 31116055 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Conclusions: Our results at the very least can support that laparoscopic surgery for rectal cancer is a safe and feasible option for patients taking long-term AT discontinued perioperatively. PMID: 31116623 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Publication date: Available online 22 May 2019Source: Pathology - Research and PracticeAuthor(s): Hui Wang, Chaturika HerathABSTRACTSignet ring cell mesothelioma is a rare variant of epithelioid mesothelioma with limited cases published. It has a male predilection and most commonly occurs on pleura; it can also arise in the peritoneal cavity. The signet ring cell morphology can pose a challenge leading to a potential diagnostic error. A variety of benign and malignant diseases, including reactive histiocytic hyperplasia, adenocarcinoma, melanoma, and lymphoma with signet ring cell morphology should be considered in the dif...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, we aimed to investigate the expression signatures of exosomal miRNAs and develop a serum exosome-derived miRNA panel for diagnosis of non-small cell lung cancer (NSCLC). The miR-17-92 cluster including 6 miRNAs (miR-17-5p, miR-18a-5p, miR-19a-3p, miR-19b-1-5p, miR-20a-5p and miR-92a-1-5p) was selected as potential diagnostic candidate molecule. Then, expression profiles of the candidate miRNAs were firstly analyzed in 43 pairs of serum samples from the training set by quantitative real-time PCR, and the dysregulated miRNA along with three tumor markers (carcinoembryonic antigen, CEA; cytokeratin 19 fragment,...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 22 May 2019Source: Pathology - Research and PracticeAuthor(s): Song Wan, Ming Xi, Hai-Bo Zhao, Wei Hua, Yuan-Ling Liu, Yu-Lin Zhou, Yang-Jia Zhuo, Ze-Zhen Liu, Zhi-Duan Cai, Yue-Ping Wan, Wei-De ZhongAbstractBackgroundAccumulating studies reported that 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) may function as either an oncogene or a tumor suppressor in various human cancers. However, its involvement in prostate cancer (PCa) remains unknown. Therefore, the aim of this study was to investigate the clinical significance of HMGCS2 expression and its functions in PCa.MethodsExpression...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusions: miR-147b not only plays important roles in the regulation of cell proliferation and tumor growth in CRC, which might be a potential prognostic marker or therapeutic target for CRC.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research
We describe a case that highlights the importance of a detailed family history.Case Rep Ophthalmol 2019;10:180 –185
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
Conclusion: The BHDS can be associated with tumors of the skin and kidney. In this case, we noted ocular melanocytosis, malignant choroidal melanoma, and bilateral pinpoint retinal pigment epithelial detachments.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
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