Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults.
Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults. Acta Derm Venereol. 2015 Sep 9; Authors: Huang YC, Shindel AW, Chen CS, Huang YK, Wu CF, Lin JH, Chiu KH, Shi CS Abstract Diabetes is usually asymptomatic in its early stage. Early diagnosis may improve outcomes by enabling initiation of treatment before end organ damage has progressed. The aim of this study was to determine whether the clinical sign of phimosis with preputial fissures is predictive of type 2 diabetes in patients not previously diagnosed with diabetes. Twenty-eight patients with acquired phimosis and preputial fissures were collected prospectively. Twenty-eight controls with acquired phimosis without preputial fissures were selected. Statistically significant differences were found in body mass index, random plasma glucose, glucosuria and glycosylated haemoglobin levels, but not in age, family history of diabetes, hypertension and classical hyperglycaemic symptoms. Diabetes was confirmed in all 28 (100%) patients in the preputial fissures group, but only 2 (7.1%) patients in the non-preputial fissures group (p
ConclusionsDiabetic nephropathy was common among Chinese patients with type 2 diabetes in primary care in Hong Kong. Early identification and control of the modifiable risk factors are of upmost importance in preventing the complication.
Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Eman Soliman, Shereen F. Behairy, Nabila N. El-maraghy, Shimaa M. ElshazlyAbstractPeroxisome proliferator-activated receptor γ (PPAR-γ) agonist, pioglitazone, is used clinically to improve the glycemic state in patients with type-2 diabetes mellitus. Independent of its blood glucose-lowering properties, pioglitazone ameliorates different cardiovascular disorders. The aim of the present study was to investigate the effect of pioglitazone on cardiovascular complications of N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensi...
ConclusionLV mass and diastolic function were not affected after 1 year of metformin treatment in patients with T2DM. However, we observed benefits in terms of reductions in both BMI and LDL-C levels and preservation of renal function.Trial RegistrationUMIN000006504. Registered 7 October 2011.
ConclusionsIn Japanese patients with type 2 diabetes mellitus, linagliptin produced sustained reductions in HbA1c and had a safety profile consistent with the established safety profile of linagliptin.Trial RegistrationClinicalTrials.gov (NCT01650259).
This study was designed to evaluate the influences of long-term metformin prescription in these patients.
A 59-year-old man with type 2 diabetes mellitus and hypertension presented to the emergency department with a 4-day history of coughing and an intermittent fever. He had received ultrasonography-guided percutaneous puncture via left flank with ethanol injection for renal cyst sclerosing therapy approximately 2 weeks earlier. On physical examination, he was well oriented and febrile (39.8°C) with high blood pressure (194/88 mm Hg) and tachycardia (heart rate 131 beats/min). His abdomen and back were soft without tenderness or erythematous change.
AbstractBackgroundDipeptidyl peptidase-4 (DPP-4) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors are widely used antidiabetic drugs. However, to date, no studies have directly compared the effects of these two drugs on the components of the metabolic syndrome in patients with type 2 diabetes mellitus (T2DM).ObjectivesThe Comparison of Canagliflozin vs. Teneligliptin against Basic Metabolic Risks in Patients with T2DM (CANTABILE) study aims to examine whether the DPP-4 inhibitor (teneligliptin) or the SGLT2 inhibitor (canagliflozin) is the more effective drug for reducing metabolic risk factors as a compos...
ConclusionDiabetes prevalence was 6.9% and was higher in older people, people with hypertension, alcohol consumers and abdominally obese men.
Publication date: Available online 23 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Margarida Lorigo, Melissa Mariana, Manuel C. Lemos, Elisa CairraoAbstractTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may be related to th...
Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disease, which is increasing dramatically worldwide [1,2]. For T2DM patients with hypertension, lipid levels and blood pressure control is important to prevent cardiovascular disease complications [3,4]. Poorly controlled blood glucose can cause both macrovascular and microvascular complications . Glycated hemoglobin (HbA1c) has been proven as a more comprehensive measure of total glycemic control than fasting plasma glucose, and it is highly associated with the presence of diabetic micro-vascular complications in prospective studies .