Quantitative Analysis of Formaldehyde-induced Fluorescence in Paraffin-embedded Specimens of Malignant Melanomas and Other Melanocytic Lesions.

This study compared 2 sets of excitation and emission bands: 450-490 nm excitation/510-560 nm absorption filters (filter unit A) and 480 nm excitation/510
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Cases of melanoma fell among people younger than 30 in the United States from 2006 to 2015, suggesting efforts to encourage protection from the sun are paying off, a new study says.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
WEDNESDAY, Nov. 13, 2019 -- Melanoma incidence seems to be decreasing in adolescents and young adults, according to a study published online Nov. 13 in JAMA Dermatology. Kelly G. Paulson, M.D., Ph.D., from the Fred Hutchinson Cancer Research Center...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
A new study from University of Washington School of Medicine has found that rates of melanoma fell 4% per year among young men and 4.5% among young women from 2005 to 2015.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We examined the rates and predictors of slnb and clnd for melanoma patients in Ontario (population 13.6 million) after publication of that guideline. Methods: We used the Ontario Cancer Registry to identify patients diagnosed with cutaneous melanoma in 2013. Patient records were linked to prospectively maintained health administrative databases to obtain details for each patient, including surgical procedures. Results: Of the 3298 patients with melanoma identified in Ontario in 2013, 1973 (59.8%) could be analyzed. Most of that group (n = 1227, 62.2%) underwent local excision alone; 746 (37.8%) had a slnb. The slnb...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Condition:   Focus of Study: Patients With Suspicion of Melanoma Intervention:   Device: Nevisense Sponsor:   SciBase AB Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The downward trend suggests sun-wise public health campaigns may be favorably influencing melanoma incidence, mirroring what has been seen in Australia.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Interview with Jennifer Gardner, MD, and Deepti Gupta, MD, authors of Age-Specific Incidence of Melanoma in the United States
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
The objective of this study was to validate the conjunctival melanoma staging criteria in the American Joint Committee on Cancer (AJCC) Cancer Staging Manual (8th edition) and explore the prognostic importance of tumor thickness, histologic ulceration, and sentinel lymph node biopsy (SLNB) findings in patients with conjunctival melanoma. This is a case series of 88 consecutive patients with conjunctival melanoma. Clinicopathologic characteristics were analyzed. Associations between pathologic characteristics and outcomes were studied using Kaplan-Meier survival analysis. Local recurrence, lymph node metastasis, distant met...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Spitz melanoma is a rare variant of melanoma defined by distinct clinical, histologic, and genetic features and affecting patients of all ages. Half of these tumors are driven by fusion of kinase genes including ALK, NTRK1/3, ROS1, RET, MET, or BRAF. We recently reported recurrent fusion or truncation of the potentially targetable serine-threonine kinase gene MAP3K8 in 33% of Spitz melanomas. Here we describe the histologic features of these MAP3K8-rearranged tumors (16 pediatric Spitz melanomas; 1 atypical Spitz tumor), using hematoxylin-eosin slides, p16 immunohistochemistry, and CDKN2A fluorescence in situ hybridization...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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