Metabolic Syndrome Predicts Refractoriness to Intravenous Thrombolysis in Acute Ischemic Stroke

Background: Metabolic syndrome (MetS) has been associated with higher resistance to clot lysis at 24 hours after tissue plasminogen activator (tPA) administration in patients with acute ischemic stroke. We aimed to test this hypothesis at earlier time points, when neurointerventional rescue procedures may still be indicated to achieve arterial recanalization. Methods: This is a prospective and observational study in consecutive stroke patients with MCA occlusion treated with IV tPA. MetS was diagnosed following the unified criteria of the last Joint Interim Statement 2009 participating several major organizations.

Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2015 Category: Neurology Authors: Laura Dorado, Juan F Arenillas, Elena López-Cancio, María Hernández-Pérez, Natalia Pérez de la Ossa, Meritxell Gomis, Mònica Millán, María Luisa Granada, Amparo Galán, Ernest Palomeras, Antoni Dávalos Source Type: research