Case report: veno-venous ECMO as a bridge to lung transplantation in paraquat poisoning

3 out of 5 stars Successful extracorporeal membrane oxygenation therapy as a bridge to sequential bilateral lung transplantation for a patient after severe paraquat poisoning. Tang X et al.  Clin Toxicol 2015 Aug 28 [Epub ahead of print] Abstract Conceptually, extracorporeal membrane oxygenation (ECMO) seems a perfect technique for treating some of the sickest toxicology patients,  buying time until failing vital functions can recover. With severe cardiotoxins — for example, calcium channel blockers, beta blockers or bupropion — veno-arterial ECMO can provide complete cardiopulmonary bypass, replacing both cardiac and pulmonary function. In the case of severe poisoning with paraquat — a highly toxic herbicide that causes progressive respiratory failure and irreversible pulmonary fibrosis — veno-venous ECMO can replace support pulmonary function and serve as a bridge to lung transplantation. This paper from Beijing Chao-Yang Hospital describes what is, to my knowledge, the first case in which v-v ECMO has been used successfully to treat paraquat poisoning. A 24-year-old, 53-kg woman ingested an estimated 50 ml of 20% paraquat.She arrived at hospital 2 hours later and was initially treated with gastric lavage, laxatives, and activated charcoal. Additional treatment included cyclosphophamide, steroids, and hemoperfusion. Unfortunately, her initial signs and symptoms are not well-described. Three days after presentation, the patie...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical ECMO extracorporeal membrane oxygenation lung transplantation paraquat poisoning Source Type: news

Related Links:

Abstract Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these poisons have many other molecules that may have important biological actions. Therefore, this work evaluated the action of the low molecular weight components from Rhinella schneideri toad poison on Na+/K+-ATPase and their anticonvulsive and / or neurotoxic effects, in order to detect molecules with acti...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
(Natural News) Today, the internet, often thought of as our world’s “final frontier” for free thinkers and the flow and exchange of ideas and information, is seriously ill. It has been systemically infected by ideological viruses, memes of information intent on poisoning freedom of expression that we take for granted every time we use Google...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Carbon monoxide poisoning. Carbon monoxide poisoning is a frequent and serious intoxication with an important pre-hospital mortality. The diagnosis is made by the association of a context and compatible neurological and cardiac clinical signs. This diagnos...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: Acute poisoning in geriatric age group is a clinical challenge due to multiple comorbidities and complications in this age group. There are very few studies done in the past, which have addressed this issue. MATERIALS AND METHODS: This ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: 16 April 2019Source: Cell Reports, Volume 27, Issue 3Author(s): Valentina Sica, Jose Manuel Bravo-San Pedro, Valentina Izzo, Jonathan Pol, Sandra Pierredon, David Enot, Sylvère Durand, Noélie Bossut, Alexis Chery, Sylvie Souquere, Gerard Pierron, Evangelia Vartholomaiou, Naoufal Zamzami, Thierry Soussi, Allan Sauvat, Laura Mondragón, Oliver Kepp, Lorenzo Galluzzi, Jean-Claude Martinou, Holger Hess-StumppSummaryInhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-y...
Source: Cell Reports - Category: Cytology Source Type: research
Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are dele...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 April 2019Source: Toxicology ReportsAuthor(s): S. Hameed Kadar Ali, Wasim Ali RajaAbstractObjectiveTo study the effect of Antioxidants supplementation in reducing oxidative stress induced in acute amitriptyline poisoning cases.Design and methodsWe compared the effect of supplementation of treatment of acute amitriptyline poisoning cases with alpha lipoic acid alone or with vitamin C, with that of those receiving only routine standard treatment (RST) as a control group.A total of 132 subjects divided into 5 groups were selected from IMCU (Intensive Medical Care Unit) and Toxicology Ward...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Publication date: April 2019Source: Harmful Algae, Volume 84Author(s): Lucía Soliño, Joan Ferrer-Obiol, Leia Navarro-Herrero, Jacob González-Solís, Pedro Reis CostaAbstractMarine birds have been hypothesized to be underreported victims of harmful algal blooms (HABs). Toxic blooms of Pseudo-nitzschia spp., the primary amnesic toxin producer microalgae, domoic acid (DA) are known to cause massive mortalities of coastal seabirds and marine mammals around the world. However, these fatalities are only detected when birds die nearby the coastline and little is known about possible outbreaks of pelagic...
Source: Harmful Algae - Category: Environmental Health Source Type: research
Authors: Spilchuk V, Thompson A PMID: 30988044 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
We report five cases of nephrotic syndrome caused by MN with evidence of chronic mercury poisoning due to consumption of traditional Indian...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
More News: Beta-Blockers | Bupropion | Calcium | Cardiology | Celexa | Citalopram | Emergency Medicine | Gastric Lavage | Gastroenterology | Heart | Hospitals | Lung Transplant | Podcasts | Poisoning | Psychology | Rehabilitation | Respiratory Medicine | Toxicology | Transplant Surgery | Transplants | Websites | Wellbutrin