Tim-3 fosters HCC development by enhancing TGF-{beta}-mediated alternative activation of macrophages

Conclusions
Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC. Interference of Tim-3 might be great potential in HCC therapy.

Source: Gut - September 8, 2015 Category: Gastroenterology Authors: Yan, W., Liu, X., Ma, H., Zhang, H., Song, X., Gao, L., Liang, X., Ma, C. Tags: Hepatic cancer Hepatology Source Type: research