APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma
Conclusions
APR-246 has significant antitumour activity in OAC. Given that APR-246 is safe at therapeutic levels our study strongly suggests that APR-246 can be translated into improving the clinical outcomes for OAC patients.
Source: Gut - Category: Gastroenterology Authors: Liu, D. S. H., Read, M., Cullinane, C., Azar, W. J., Fennell, C. M., Montgomery, K. G., Haupt, S., Haupt, Y., Wiman, K. G., Duong, C. P., Clemons, N. J., Phillips, W. A. Tags: Oesophageal cancer Oesophagus Source Type: research
More News: Adenocarcinoma | Cancer | Cancer & Oncology | Clinical Trials | Esophagus Cancer | Gastroenterology | Genetics | Oesophagus | Study