Treatment Progress of Paroxysmal Sympathetic Hyperactivity after Acquired Brain Injury

Paroxysmal sympathetic hyperactivity (PSH) is a common complication of various acquired brain injuries such as traumatic brain injury, subarachnoid hemorrhage, anoxic brain injury, intracerebral hemorrhage, and others. It is manifested by tachycardia, hypertension, tachypnea, diaphoresis, and dystonic posturing. The development of PSH can prolong hospitalization and lead to secondary brain injury and even death. Despite the awareness of the serious clinical impact, there is no consensus on diagnostic criteria. Thus, misdiagnosis and delayed recognition is very common. Most of the current treatment programs come from case reports and small case series; there are very few large-scale randomized controlled trials. Generally accepted medications are opioids, β-blockers and gabapentin (usually used in combination). However, the efficacy of these drugs has not been systematically assessed. The purpose of this review is to determine the treatment strategies and drugs commonly used for PSH at the overall level.Pediatr Neurosurg
Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research

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The objective of the study was to compare the results of caloric reflex tests and video head impulse tests (vHITs) of lateral semicircular canals (SCCs).MethodsPatients aged over 18  years diagnosed with definite Ménière’s disease (MD) according to the AAO–HNS 1995 criteria were recruited. Audiological tests, caloric tests and vHITs were conducted on all participants. A caloric weakness (canal paresis) of >  25% was considered significant. A VOR gain of 
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Cardiology CasesAuthor(s): Chiaki Goten, Soichiro Usui, Takuto Hamaoka, Tomoya Harada, Oto Inoue, Hirofumi Okada, Shin-ichiro Takashima, Takeshi Kato, Hisayoshi Murai, Kenji Sakata, Hiroshi Furusho, Masa-aki Kawashiri, Masayuki TakamuraAbstractThe prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Conclusion Myocardial perfusion defects, both in RV and LV, occur even in asymptomatic or mildly symptomatic patients with Eisenmenger syndrome.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Charleen Salesse, Julien Charest, Hélène Doucet-Beaupré, Anne-Marie Castonguay, Simon Labrecque, Paul De Koninck, Martin LévesqueSummaryThe neurodevelopmental origin of hyperactivity disorder has been suggested to involve the dopaminergic system, but the underlying mechanisms are still unknown. Here, transcription factors Lmx1a and Lmx1b are shown to be essential for midbrain dopaminergic (mDA) neuron excitatory synaptic inputs and dendritic development. Strikingly, conditional knockout (cKO) of Lmx1a/b in postm...
Source: Cell Reports - Category: Cytology Source Type: research
Women who were obese before pregnancy were approximately twice as likely to report that their child had ADHD or symptoms of hyperactivity.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Authors: Saeed S, Dweck MR, Chambers J Abstract Introduction: In aortic stenosis (AS), there are clear sex-differences in clinical presentation, left ventricular (LV) response to pressure overload, and pathophysiology of valvular calcification. These differences may affect outcome following valve intervention.Area covered: This review aims to discuss sex-differences in clinical presentation, pathophysiology of aortic valve calcification, LV remodeling in view of historic and recent echocardiographic and cardiac magnetic resonance imaging studies, and outcome after valve intervention. In addition, it will also provi...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
This article also discusses the clinical trials on treatment of hypertension in the elderly, the 2018 European Society of Cardiology/European Society of Hypertension hypertension guidelines, and the treatment of hypertension and of resistant hypertension in the elderly. For elderly adults with hypertension and a high burden of comorbidities and limited life expectancy, clinical judgment, patient preference, and a team-based approach to assess risk/benefit is reasonable for decisions about the intensity of SBP lowering and the choice of antihypertensive drugs to use for treatment. Randomized clinical trials need to be perfo...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Conclusion: In general, MA-IL was well tolerated and although associated with local and systemic adverse events, there was a low risk of high intensity or severe complications. PMID: 32067521 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: Our data support the adoption of the surgical management of the morbidly obese patient. Although short term complication rates are higher with increasing obesity (II-III class), a majority of procedures can still be completed with minimally invasive approach. PMID: 32064825 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
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