Doctor's Diary: Help for IBS sufferers may be on the way
New and emerging treatments for those with Irritable Bowel Syndrome will help diagnose their digestive problems
According to this study: Although many patients report having an allergy to penicillin, few have clinically significant immunoglobulin-mediated or T lymphocyte–mediated penicillin hypersensitivity.Clinicians should evaluate penicillin allergy before ruling out the use of penicillin or other beta-lactam antibiotics.
Condition: Chronic Pain Interventions: Procedure: radiofrequency splanchnic denervation; Procedure: retrocrural celiac denervation Sponsor: Assiut University Not yet recruiting
Publication date: Available online 21 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Victoria Ribeiro, Jade Andrade, Samantha Rose, Chantal Spencer, Alfin Vicencio, Supinda Bunyavanich
Conclusions: Cte f 2 induces IgE and IgG production as well as T-cell proliferation in children living in a geographical area where PU induced by a flea bite is common. The use ofC. felis extract is not recommended for the study of bite-induced hypersensitivity disease since salivary antigens are not well represented.Int Arch Allergy Immunol
Recurrent severe bacterial and fungal infections are characteristic features of the rare genetic immunodeficiency disorder chronic granulomatous disease (CGD). The disease usually manifests within the first years of life with an incidence of 1 in approximately 200,000 live births. The incidence is higher in Iran and Morocco where it reaches 1.5 per 100,000 live births. Mutations have been described in the 5 subunits of NADPH oxidase, mostly in gp91phox and p47phox, with fewer mutations reported in p67phox, p22phox, and p40phox. These mutations cause loss of superoxide production in phagocytic cells.CYBB, the gene encoding ...
This article presents the American College of Gastroenterology's updated guidelines on managing Crohn's disease in adult patients.U.S. Pharmacist
Lejeune T, Roncontrati P, Lefebvre PP, Delvenne P, and ElShazly AE
PMID: 30896497 [PubMed - in process]
Abstract BACKGROUND AND OBJECTIVES: The safety and tolerability of hydrolysed cow's milk protein-based formulas, particularly partially hydrolysed formulas (pHFs), in children with cow's milk allergy (CMA) remain poorly understood. We evaluated the tolerability of hydrolysed cow's milk-based formulas in children with CMA. METHODS AND STUDY DESIGN: A three-period double-blind crossover evaluation compared the allergic tolerance against three dietary cow's milk-based formulas: extensively hydrolysed cow's milk formula (eHF), pHF, and regular cow's milk formula (rCMF). The primary outcome was the rate of toleran...
CONCLUSION: An educational program to increase medical awareness of the national guidelines and mandatory notification of all anaphylactic reactions should be implemented. PMID: 30896389 [PubMed - in process]