Publication date: Available online 4 September 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): David J. Mayhew, Kenneth Palmer Inotropes are a heterogenous group of drugs that modify calcium handling and alter the force of myocardial contraction. Catecholamines, and their synthetic analogues, increase intracellular calcium by activating cyclic adenosine monophosphate (cAMP) or inositol triphosphate (IP3). Phosphodiesterase inhibitors block phosphodiesterase 3, which in turn reduces catabolism of cyclic nucleotides cAMP and cyclic guanosine monophosphate (cGMP), again increasing intracellular calcium. Cardiac glycosides inhibit the Na+/K+ exchanger, and subsequent electrochemical reversal of the Na+/Ca2+ exchanger causes Ca2+ to rise. Rising intracellular calcium increases inotropy, but risks cardiac arrhythmia, work–perfusion mismatching and myocardial contraction band necrosis. It also risks peripheral ischaemia as intense vasoconstriction is seen with many agents. These effects can be limited by combining low doses of a number of agents, and by understanding the underlying pathology. Novel agents, such as omecamtiv, have multiple beneficial actions, but do not raise intracellular calcium. Their use may become more widespread if clinical data support their efficacy. Inotropes are most often delivered as a central intravenous infusion, commenced and monitored on the intensive care unit with invasive blood pressure and cardiac output monitoring avail...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research

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Conclusions The study shows high fatality caused by cardiovascular diseases and drug intoxication among schizophrenia patients, which calls attention of the medical community to closely monitor the high risk factors of sudden death among schizophrenia patients.
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Original Articles Source Type: research
Authors: Mazkereth R, Maayan-Metzger A, Leibovitch L, Schushan-Eisen I, Morag I, Straus T Abstract BACKGROUND: The need for postnatal monitoring of infants exposed to intrauterine beta blockers (BBs) has not been clearly defined. OBJECTIVES: To evaluate infants exposed to intrauterine BBs in order to estimate the need for postnatal monitoring. METHODS: This retrospective case-control study comprised 153 term infants born to mothers who had been treated with BBs during pregnancy. Treatment indications included hypertension 76 mothers (49.7%), cardiac arrhythmias 48 (31.4%), rheumatic heart disease 14 (9.1%),...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
This article reviews and compares the most recent guidelines and consensus document on AF catheter ablation.
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
Publication date: Available online 13 November 2019Source: Pharmacological ResearchAuthor(s): Juthipong Benjanuwattra, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon C. hattipakornAbstractThe cancer burden on health and socioeconomics remains exceedingly high, with more than ten million new cases reported worldwide in 2018. The financial cost of managing cancer patients has great economic impact on both an individual and societal levels. Currently, many chemotherapeutic agents are available to treat various malignancies. One of these agents is doxorubicin, which was isolated from Streptomyces peucetius in the 1960...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: FELLOWS CORE CURRICULUM Source Type: research
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Anxiety and depression may activate the autonomic nervous system which is likely to play an important role in the etiology of AF. However, little is known about the association between symptoms of anxiety and depression and risk of AF.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
In this study, an 11-layer deep convolutional neural network model is proposed for classification of the MIT-BIH arrhythmia database into five classes according to the ANSI –AAMI standards. In this CNN model, we designed a complete end-to-end structure of the classification method and applied without the denoising process of the database. The major advantage of the new methodology proposed is that the number of classifications will reduce and also the need to detect, and segment the QRS complexes, obviated. This MIT-BIH database has been artificially oversampled to handle the minority classes, class imbalance problem...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
Authors: Kageyama K, Kinoshita N, Terui K, Moriyama T, Kudo T, Daimon M Abstract Giant internal carotid artery aneurysms sometimes extend into the sellar region, which rarely but occasionally results in hypopituitarism due to the compression of the normal pituitary gland or hypothalamus. Hyponatremia is a known complication of hypopituitarism. We herein report two cases of hypopituitarism caused by intrasellar aneurysm of different origins, resulting in hyponatremia. Untreated hypopituitarism may lead to lethargy, coma, cardiac arrhythmia, and death. Therefore, we must be alert for the occurrence of giant intrasell...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Use of marijuana is linked to a higher risk of stroke and hospitalization for cardiac arrhythmia in young people, two new studies suggest.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
Publication date: Available online 11 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Péter P. Nánási, Zoltán Szabó, Kornél Kistamás, Balázs Horváth, László Virág, Norbert Jost, Tamás Bányász, János Almássy, András VarróAbstractIt has long been known that the electrophysiological effects of many cardioactive drugs strongly depend on the rate dependent frequency. This was recognized first for class I antiarrhythmic agents: their Vmax suppressive effect was attenuate...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
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