Cell fusion in Neurospora crassa.

Cell fusion in Neurospora crassa.
Curr Opin Microbiol. 2015 Sep 1;28:53-59
Authors: Herzog S, Schumann MR, Fleißner A
Abstract
In recent years, the filamentous fungus Neurospora crassa has advanced as a model organism for studying eukaryotic cell-cell communication and fusion. Cell merger in this fungus employs an unusual mode of communication, in which the fusion partners appear to switch between signal sending and receiving. Many molecular factors mediating this intriguing mechanism and the subsequent membrane merger have been identified. It has become apparent that conserved factors, such as MAP kinases, NADPH oxidases and the STRIPAK complex, together with fungal specific proteins are wired into an intricate signaling network. Here, we will present an overview of recent findings on the molecular mechanism mediating fusion in N. crassa and will discuss the current working model.
PMID: 26340439 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - September 1, 2015 Category: Microbiology Authors: Herzog S, Schumann MR, Fleißner A Tags: Curr Opin Microbiol Source Type: research