Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort.
Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort.
Am J Physiol Renal Physiol. 2015 Sep 2;:ajprenal.00326.2015
Authors: Rojas-Vega L, Jimenez AR, Bazua-Valenti S, Arroyo-Garza I, Jimenez JV, Gomez-Ocadiz R, Carrillo-Perez DL, Moreno E, Morales-Buenrostro LE, Alberú J, Gamba G
Abstract
Evidences in rodents suggest that tacrolimus-induced post-transplant hypertension is due to upregulation of the thiazide-sensitive Na+-Cl- cotransporter, NCC. Here we analyzed if a similar mechanism is involve in post-transplant hypertension in humans. From January 2013 to June 2014 all adult kidney transplant recipients receiving a kidney allograft were enrolled into a prospective cohort study. All patients received tacrolimus as part of the immunosuppressive therapy. Six months after surgery we assessed general clinical and laboratory variables, tacrolimus trough blood levels, and ambulatory 24-hour blood pressure monitoring. Urinary exosomes were extracted to perform Western blot analysis using total and phospho-NCC antibodies. A total of 52 patients, including 17 women and 35 men, were followed. At six months after transplantation, of the 35 men, 17 developed hypertension and 18 remained normotensive, while high blood pressure was observed in only 3 out 17 women. The hypertensive patients were significantly older than the normotensive group, however ther...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Rojas-Vega L, Jimenez AR, Bazua-Valenti S, Arroyo-Garza I, Jimenez JV, Gomez-Ocadiz R, Carrillo-Perez DL, Moreno E, Morales-Buenrostro LE, Alberú J, Gamba G Tags: Am J Physiol Renal Physiol Source Type: research
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