Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group.

CONCLUSION: These first steps in evaluating the validity of US as an outcome measure for gout show that the reliability of the definitions ranged from moderate to excellent in static images and somewhat lower in patients, indicating that a standardized scanning technique may be needed, before testing the responsiveness of those definitions in a composite US score. PMID: 26329333 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research

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ConclusionsThese results raise the possibility that pannexin1 is a novel therapeutic target for the treatment of AUD. The clinical use of probenecid has been found to be generally safe, suggesting that it can be a candidate for drug repositioning for the treatment of AUD.
Source: Alcohol and Alcoholism - Category: Addiction Source Type: research
ConclusionsMost subjects were females and developed calcinosis in adulthood. Small joints (hand and wrist) and the upper limbs were frequently involved. The presence of different phases of pathological features in the same subject suggests that about half of the study participants had been misdiagnosed with another condition (such as gout, osteoarthritis, etc.). Complete surgical excision led to cure without recurrence during follow-up in majority of the study participants.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Authors: Malewska-Kasprzak MK, Permoda-Osip A, Rybakowski J Abstract Purinergic system plays a role in the regulation of many psychological processes, including mood and activity. It consists of P1 receptors, with adenosine as the agonist, and P2 receptors, activated by nucleotides (e.g., adenosine 5'-triphosphate - ATP). Propounded disturbances of uric acid in affective disorders were related to the introduction of lithium for the treatment of these disorders in the 19th and 20th century. At the beginning of the 21st century, new evidence was accumulated concerning a role of uric acid in the pathogenesis and treat...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Russell M, Yates M, Bechman K, Rutherford A, Subesinghe S, Lanyon P, Galloway J Abstract OBJECTIVE: To describe trends in acute hospital admissions due to gout in England, with rheumatoid arthritis (RA) as a comparator, alongside prescribing trends for common gout medications. METHODS: An ecological study was performed using NHS Digital Hospital Episode Statistics data to calculate the incidence of unplanned admissions with primary diagnoses of gout or RA in adults in England between April 2006 and March 2017. NHS Digital community prescription data for allopurinol, febuxostat and colchicine were consi...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
ConclusionsPatients with high BMI, CKD, and pre ‐treatment hyperuricemia are at a higher risk of gout attack during TB treatment.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsUsing a novel dose-titration method, although the primary endpoint of non-inferiority of febuxostat 40  mg/day versus allopurinol 300 mg/day was not reached, non-inferiority and superiority of febuxostat 60 mg/day and 80 mg/day versus allopurinol 300 mg/day was demonstrated at weeks 16 and 24, respectively. Febuxostat demonstrated an acceptable tolerability profile in the treatment of hyperurice mia in Chinese subjects with or without gout.Trial RegistrationJapicCTI-132106.FundingAstellas Pharma Global Development, Inc.
Source: Rheumatology and Therapy - Category: Rheumatology Source Type: research
Updated Date: Mon, 16 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
We report a case of gout involved cervical disc and adja...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Case report Source Type: research
Conditions:   Uncontrolled Gout;   Kidney Transplant Intervention:   Biological: Pegloticase Sponsor:   Horizon Pharma Rheumatology LLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Uncontrolled Gout;   Kidney Transplant Intervention:   Biological: Pegloticase Sponsor:   Horizon Pharma Rheumatology LLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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