Scientists Use DNA 'Velcro' To Print Human Tissue In The Lab

We need more organs. At any given moment, more than 123,000 Americans are waiting for an organ transplant. Each year, 6,500 of them die for want of a donor. Moreover, between 15 and 50 percent of patients lucky enough to receive a transplant from a donor -- depending on the organ -- suffer from acute organ rejection within five years. For that reason, scientists across the country are racing to develop a way to grow organs in the lab. The dream is to eventually use a patient's own cells to construct new kidneys, livers, hearts and lungs that would be impervious to rejection by their immune systems -- in other words, a way to let patients be their own organ donors.  What makes this hard is that the techniques humans use for manufacturing most things don't work for organs. A car "has lots of pieces, and they fit together very nicely, and they're guided to the correct position by a human hand or a robot, and then welded together into this complex machine," said Dr. Zev Gartner, an associate professor of pharmaceutical chemistry at the University of California, San Francisco. "Tissues and organs, on the other hand, self-assemble in a process that's guided by rules that are quite distinct from the way that we as humans think about building stuff." One key challenge is getting blood vessels to the right place. It's essential, because blood vessels deliver life-sustaining oxygen and nutrients to the cells, but the tiny...
Source: Science - The Huffington Post - Category: Science Source Type: news

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This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study aimed to investigate the effects of various perfusion temperatures on lung graft preservation during ex vivo lung perfusion (EVLP).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 583 Source Type: research
Cervical cancer is the most common gynecological cancer worlwide. Squamous intraepithelial lesions (SIL) are known precursors for carcinoma of uterine c èrvix and associated to infection by human papillomavirus (HPV). Several studies have shown an increased risk of malignant anogenital lesions in recipients of kidney and liver transplants compared to the general population, but there is less information in heart transplanted recipient
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 987 Source Type: research
Right heart failure following left ventricular assist device implantation is one of the major challenges in patients suffering from advanced heart failure. There is still no ideal right-sided support system available. Here we describe the implantation of a stent valve at the inferior cavoatrial junction to protect liver and kidney during right heart failure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 920 Source Type: research
The impact of opioid use in lung transplant (LTx) candidates on post-transplant outcomes is unknown. Previous studies on opioid therapy in kidney and liver transplant candidates have suggested increased risk of graft failure or death. We sought to test the association between pre-transplant opioid use in LTx candidates and overall retransplant-free survival.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1050 Source Type: research
The Model of End-Stage Liver Disease (MELD) score incorporates measures of kidney and liver dysfunction. MELD score has been shown to predict mortality in patients with advanced heart failure or cardiogenic shock (CS). Prior small single-center studies have shown that MELD score predicts mortality in patients supported with Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). The Purpose of our was to reassess the role of MELD score predicting Mortality After (VA-ECMO).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1099 Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions. Childhood transplant recipients have a 30 times greater cancer incidence versus the general population. Further investigation is needed to guide screening strategies in this at-risk population.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Publication date: Available online 16 February 2019Source: Social Science &MedicineAuthor(s): Athena EngmanAbstractThe concept of biographical disruption has now enjoyed nearly 40 years of use in medical sociology. This paper argues that taking an embodied approach to biographical disruption helps to explain the concept's enduring efficacy. Drawing on the work of Maurice Merleau-Ponty and contemporary theories of embodiment inspired by his phenomenology, this paper advances that biographical disruption involves, in the first instance, a disruption to the ability to enact an embodied orientation towards the world. Biogr...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Since the advent of lung transplantation, chronic lung allograft dysfunction (CLAD) has been the number one cause of long-term mortality.1 A subset of T cells, known as regulatory T cells (Tregs), have been shown to suppress inflammatory responses after organ transplantation. Much of what is known about the role of Tregs in suppressing alloimmune responses has come from experimental studies of kidney, heart, pancreatic islet, liver, and bone marrow transplantation. On the basis of these findings, 2 phase I clinical trials in which adoptively transferred Tregs were administered after kidney transplantation have been completed.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
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