Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines

Conclusion: AARS, AURKA, AURKB, CENPA, CCNB1, CCNE2, and CDK may contribute to MTX resistance via aminoacyl-tRNA biosynthesis pathway, cell cycle pathway, or p53 signaling pathway.
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Source Type: research