The role of β-catenin in bcr/abl negative myeloproliferative neoplasms: an immunohistochemical study

Conclusions This study suggests that Wnt/ β-catenin signaling pathway has a role in the angiogenesis of PMF and in the thrombopoiesis of PV and ET. Hence, targeting Wnt/ β-catenin signaling pathway could open new avenues for novel therapeutic approaches in bcr/abl negative myeloproliferative neoplasms. Teaser The dysregulation of Wnt/ β-catenin signaling pathway causes to various diseases. In this study we aimed to reveal the role of β-catenin in bcr/abl nagative MPN. The expression of β-catenin was examined in bone marrow with immunohistochemical method in 66 patients and in 30 controls. The results suggest that β-catenin has a role in the angiogenesis of PMF and in the thrombopoiesis of PV and ET.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research