Brazilian Wasp's Venom Could Be A Powerful 'Weapon Against Cancer,' Study Shows

Toxic, but life-saving? It seems like an oxymoron, but scientists say the venom of Polybia paulista, a wasp native to Brazil, fits that description.  According to a study published in the Biophysical Journal this week, the wasp’s venom contains a toxin, named MP1, that selectively destroys tumor cells without harming normal ones. The BBC called the venom a potentially powerful “weapon against cancer.”  In lab tests, MP1 was found to inhibit the growth of prostate and bladder cancer cells as well as leukemia cells that had been shown to be resistant to a variety of other drugs. The toxin interacts with fatty molecules known as lipids that are found on the outside of cancer cell membranes, researchers said. It then disrupts the structure of the protective membranes, creating “gaping holes” that allow molecules critical to the survival of the cancer cell to leak out. Study co-author Dr. João Neto of Brazil’s São Paulo State University said these “large” holes take “only seconds” to form. Since healthy cells don’t have these lipids on the outside (they are located on the cell's inner membrane), it seems they are not susceptible to the wasp toxin the way cancer cells are.  “Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs,” Paul Beales, one of the study’s authors, stated in a news releas...
Source: Science - The Huffington Post - Category: Science Source Type: news

Related Links:

New York health officials are investigating after significant rates of leukemia, bladder, lung and thyroid cancers were found in three Long Island counties - 16 percent of all cases in New York state.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: 5 November 2018Source: Journal of Molecular Structure, Volume 1171Author(s): Renyer A. Costa, Earle Silva A. Junior, Guilherme Braule P. Lopes, Maria Lucia B. Pinheiro, Emmanoel V. Costa, Daniel P. Bezerra, Kelson OliveiraAbstractA theoretical and experimental DFT study of the vibrational, structural and quantum properties of annomontine (1) and N-hydroxyannomontine (2) alkaloids using the B3LYP exchange-correlation functional with 6-311G (2d, p) basis set is presented. The theoretical geometry optimization data of the two structures were compared with the X-ray data of (1) in the associated literature an...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Conclusion: This study provided latest evidence on epidemiology of cancer in the southeast of Iran that could be used to empower prevention and control interventions in a developing country. PMID: 29936728 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
CONCLUSION: First Nations people in Canada have disproportionately high rates of certain cancers, providing evidence to support public health policy and programming. More research is needed to identify factors contributing to the significantly lower incidence observed for various cancer types. Novel methods for studying disparities in cancer incidence among First Nations people are required to support ongoing cancer control planning and advocacy. PMID: 29981110 [PubMed - as supplied by publisher]
Source: Canadian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Can J Public Health Source Type: research
Conclusion: The impacts of cancer in Taiwan are very large. Future studies must consider both quality of life and the entire impact from societal perspectives. PMID: 29872347 [PubMed]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research
Conclusions: 18F-FDG PET/CT is useful in AL amyloidosis. It can help find the associated malignancy and detect 1/3 amyloid-related tissues or organs. In organs with no physiological distribution of 18F-FDG, the detection rate is especially high.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
Conclusion The patient-based sensitivity, specificity and accuracy of WB MRI including DWI were comparable with those of PET/MRI. On the other hand, the lesion-based sensitivities of WB MRI were relatively low, mainly because of the low detectability of small lymph node metastasis. The combination of T2WI and DWI showed acceptable detectability; however, the T1WI sequence showed no additional value to detect malignant lesions on both lesion- and patient-based sensitivities.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research
Conclusions The burden of tobacco-related cancer hospitalizations is substantial in the U.S. These findings highlight the importance of tobacco prevention and cessation efforts to decrease the burden of tobacco-related cancers in the U.S.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 26 March 2018 Source:Journal of Trace Elements in Medicine and Biology Author(s): Marzena Matejczyk, Grzegorz Świderski, Renata Świsłocka, Stanisław Józef Rosochacki, Włodzimierz Lewandowski The most important problems of anti-cancer therapy include the toxicity of the drugs applied to healthy cells and the multi-drug cells resistance to chemotherapeutics. One of the most commonly used anticancer drugs is doxorubicin (DOX) used to treat certain leukemias and non-Hodgkin’s lymphomas, as well as bladder, breast, stomach, lung, ovarian, thyroid, multiple myeloma and other ...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
ConclusionWe predicted continuing falls in mortality rates from major cancer sites in the EU and its major countries to 2018. Exceptions are pancreatic cancer and lung cancer in women. Improved treatment and —above age 50 years—organized screening may account for recent favourable colorectal cancer trends.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
More News: Bladder Cancer | Cancer | Cancer & Oncology | Cancer Therapy | Learning | Leukemia | Science | Study | Toxicology | Universities & Medical Training | Websites