Brazilian Wasp's Venom Could Be A Powerful 'Weapon Against Cancer,' Study Shows

Toxic, but life-saving? It seems like an oxymoron, but scientists say the venom of Polybia paulista, a wasp native to Brazil, fits that description.  According to a study published in the Biophysical Journal this week, the wasp’s venom contains a toxin, named MP1, that selectively destroys tumor cells without harming normal ones. The BBC called the venom a potentially powerful “weapon against cancer.”  In lab tests, MP1 was found to inhibit the growth of prostate and bladder cancer cells as well as leukemia cells that had been shown to be resistant to a variety of other drugs. The toxin interacts with fatty molecules known as lipids that are found on the outside of cancer cell membranes, researchers said. It then disrupts the structure of the protective membranes, creating “gaping holes” that allow molecules critical to the survival of the cancer cell to leak out. Study co-author Dr. João Neto of Brazil’s São Paulo State University said these “large” holes take “only seconds” to form. Since healthy cells don’t have these lipids on the outside (they are located on the cell's inner membrane), it seems they are not susceptible to the wasp toxin the way cancer cells are.  “Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs,” Paul Beales, one of the study’s authors, stated in a news releas...
Source: Science - The Huffington Post - Category: Science Source Type: news

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In this study, T cells deficient in TRAF6 display enhanced T cell activation, CD28-indpendent stimulation and resistance to Treg cell-mediated suppression (176). Although TLR signaling can promote T cell resistance to Treg cells, the precise molecular mechanism remains yet to be elucidated. It is worth noting that TLR stimulation of T cells increases cytokine production (173, 177), thus future studies should delineate the effect of TLR-MyD88 signaling vs. subsequently induced cytokines in generating resistance to Treg cells. Lastly, it is also crucial to evaluate the effect of TLR signaling on regulatory T cells which also...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion In conclusion, genes that display a correlation between DNA methylation and their expression in specific tissues are responsible for significant changes in not only in developmental stages but also in adult tissues. We made this finding by using tissues that are not in developmental stages, but have developed in adults. This can either represent a change that occurs at the developmental stage, or it can be the result of epigenetic changes. This study presents a methodology that can be used by other researchers using omics data combined with different types of NGS data, and provides them with the opportunity to ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: These new findings indicated that the CCL2/CCR2 axis promoted the progression of SACC cells via recruiting and reprogramming TAMs. Targeting TAMs by blocking the CCL2/CCR2 axis might be a prospective strategy for SACC therapy. Introduction Salivary adenoid cystic carcinoma (SACC) is one of the most commonly diagnosed salivary gland malignancies, accounting for about 10% of all salivary gland neoplasms (1, 2). The typical characteristics of SACC include the recurrent growth, aggressive invasion, hematogenous metastasis, and chemotherapy refractory (2–4). Despite the great efforts paid in the treatm...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Wierzba W, Śliwczynski A, Karnafel W, Dziemidok P, Pinkas J Abstract Introduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations. Material and methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1.05.2008 and 30.09.2014. Results: Comparison of the mean incidence of selected maligna...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
ConclusionsPatients with upper gastro ‐intestinal cancers and sarcoma had the highest risk of dying from their disease. Breast cancer patients had the lowest risk. This knowledge may guide clinicians in their decisions on whether to offer OTC to girls and younger women with a life‐threatening disease.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
This study aimed to explore whether a correlation exists between the incidence and mortality of cancers and normalized internet search volumes on the big data platform, Baidu. We also assessed whether the distribution of people who searched for specific types of cancer differed by gender. Finally, we determined whether there were regional disparities among people who searched the Web for cancer-related information. Methods: Standard Boolean operators were used to choose search terms for each type of cancer. Spearman’s correlation analysis was used to explore correlations among monthly search index values for each can...
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Publication date: Available online 2 January 2019Source: Veterinary MicrobiologyAuthor(s): Russo Valeria, Roperto Franco, Taulescu Marian, Francesca De Falco, Urraro Chiara, Corrado Federica, John S. Munday, Cornel Catoi, Roperto SanteAbstractThe feline leukemia virus subgroup C receptors (FLVCRs) were originally cloned as virus receptors, but are now believed to function also as heme transporters and are expressed in a broad range of tissues in a wide range of mammalian species. Expression of FLVCR1 and FLVCR2 was investigated in 19 bovine papillomavirus-associated urinary bladder cancers and in 15 non-neoplastic samples ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 30 December 2018Source: Cancer GeneticsAuthor(s): Jianling Ji, Fariba Navid, Mathew C. Hiemenz, Maki Kaneko, Shengmei Zhou, Sulagna Saitta, Jaclyn A. BiegelAbstractGermline pathogenic variants in CBL are associated with an autosomal dominant RASopathy and an increased risk for malignancies, particularly juvenile myelomonocytic leukemia. Herein, we describe a patient with clinical features of a Noonan-spectrum disorder who developed embryonal rhabdomyosarcoma of the bladder at age two years. Tumor analysis using the OncoKids® cancer panel revealed a CBL pathogenic variant: NM_005188.3:...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
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