Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Conclusion: After colonic butyrate administration, splanchnic butyrate release was prevented in patients undergoing upper abdominal surgery. These observations imply that therapeutic colonic SCFA administration at this dose is safe. The trial was registered at clinicaltrials.gov as NCT02271802.

Source: Journal of Nutrition - September 1, 2015 Category: Nutrition Authors: van der Beek, C. M., Bloemen, J. G., van den Broek, M. A., Lenaerts, K., Venema, K., Buurman, W. A., Dejong, C. H. Tags: Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Source Type: research