Moving beyond the "LDL hypothesis".

Moving beyond the "LDL hypothesis". Vasa. 2015 Sep;44(5):333-40 Authors: Werner C, Laufs U Abstract SUMMARY: The term "LDL hypothesis" is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the "LDL-hypothesis" has been proven; the term appears to be outdated and should be replaced by "LDL causality". PMID: 26317252 [PubMed - in process]
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - Category: Surgery Authors: Tags: Vasa Source Type: research