Comment on “Diversity Outbred: A New Generation of Mouse Model”
1Institut und Poliklinik für Arbeitsmedizin, Umweltmedizin und Präventionsforschung, Universitätsklinikum Köln, Köln, Germany; 2Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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Citation: Erren TC, Slanger TE, Groß JV, Reiter RJ. 2015. Comment on “Diversity Outbred: A New Generation of Mouse Model.” Environ Health Perspect 123:A232; http://dx.doi.org/10.1289/ehp.1510098.
Address correspondence to T.C. Erren, Institut und Poliklinik für Arbeitsmedizin, Umweltmedizin und Präventionsforschung, Universitätsklinikum Köln, Kerpener Straße 62, D-50937 Köln, Germany. E-mail: tim.erren@uni-koeln.de
The authors declare they have no actual or potential competing financial interests.
Final Publication: 1 September 2015
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Diversity Outbred: A New Generation of Mouse Model
Charles W. Schmidt
A news article by Charles Schmidt propagates the Diversity Outbred mouse model to facilitate the extrapolation of toxicology findings to humans. In this regard, we would like to highlight two sources of animal diversity that could be relevant: 1) the differential—and genetically codetermined—circadian propensity for activity and rest with which the mice are born, and 2) the differential stability of circadian rhythms in later life stages of mice, to which perinatal photoperiods may contribute.
Regarding 1), humans come i...
Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Correspondence September 2015 Source Type: research
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