Total Body Photography as an Aid to Skin Self-Examination: A Patient's Perspective.

This study examined the use of total body photography as an aid to skin self-examination from the patients' perspective. A total of 179 individuals at high risk for developing melanoma who had undergone total body photography (60.5% response rate) completed a self-reported questionnaire assessing the frequency of skin self-examination, perceived usefulness of total body photography, and a variety of potential demographic, clinical and psychological factors. Only approximately half of the participants indicated skin self-examination as useful and 78.9% preferred clinical skin examination by a specialist. Finding total body photography useful was associated with having received instructions on how to perform skin self-examination, the use of a (hand)mirror, and confidence to detect changing moles. These findings allow us to develop strategies to further improve patients' self-screening behaviours. PMID: 26315708 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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(Brigham and Women's Hospital) Investigators from Brigham and Women's Hospital, in collaboration with international colleagues, present a new, quantitative technique that leverages DNA sequencing to make more sophisticated and accurate predictions about which primary melanomas are likely to recur and spread.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 17 January 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): L. Sainz-Gaspar, J. Sánchez-Bernal, L. Noguera-Morel, A. Hernández-Martín, I. Colmenero, A. TorreloAbstractA Spitz nevus is a melanocytic neoplasm of epithelioid and/or spindle cells that usually appears in childhood. These lesions are by nature benign, but their features can sometimes make them difficult to distinguish from melanomas. Spitzoid melanocytic lesions have been grouped into 3 types in recent decades: Spitz nevi, atypical Spitz tumors, and spitzoid melanomas. Atypical Spi...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Publication date: Available online 17 January 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): L. Sainz-Gaspar, J. Sánchez-Bernal, L. Noguera-Morel, Á. Hernández-Martín, I. Colmenero, A. TorreloAbstractMelanocytic neoplasms with spitzoid morphology (Spitz nevi, atypical Spitz tumors, and spitzoid melanomas) may be benign or malignant. Because the malignant potential of atypical Spitz tumors is uncertain, the proper therapeutic approach has been much debated over the years. Promising new techniques for molecular analysis have enabled better predictions of the biological ...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
We read with interest Pescarini et al. ’s article entitled ‘The diagnostic effectiveness of dermoscopy performed by Plastic Surgery Registrars trained in melanoma diagnosis’.1 The article is of great interest in highlighting the potential of plastic surgery registrar training in domains such as dermoscopy, especially for those trai nees looking to specialise in skin cancer. Training in these experiential skill domains is essential to building a diagnostic framework, and the comparable accuracy in diagnosis to Dermatologists reflects this.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
No abstract available
Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
In this study, we used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets. We first performed Gene Set Enrichment/Variation Analyses to detect immunological pathways that are altered in tumors with monosomy 3 or BAP1 deficiency. We then conducted an unsupervised clustering analysis to identify distinct immunologic molecular subtypes of uveal melanoma. We used CIBERSORT and ESTIMATE with RNA-seq data from The Cancer Genome Atlas and the GSE22138 microarray dataset to determine the sample-level immune subpopulations and immune scores of uveal melanoma samples. The Kaplan...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
AbstractA novel series of benzoxazole linked combretastatin derivatives (11a–11n) have been synthesized and confirmed by1H NMR,13C NMR, and Mass spectral analysis. The synthesized compounds (11a–11n) were screened for anticancer activity against three human cancer cell lines, Breast (MCF-7), Lung (A549), and Melanoma (A375). Most of the compounds exhibit moderate to potent anticancer activity. Among the compounds,11g,11h,11l,11m, and11n showed more potent activity than the positive control Doxorubicin. In addition, compounds11g,11l,11m, and11n were carried out their molecular docking studies on EGFR receptor (P...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
AbstractPredispositional genetic testing of children for adult-onset health risks is typically only used when prevention and screening measures have utility during childhood. Little is known about how children and their parents may use predispositional risk information, including whether it changes their interactions around risk-reducing prevention and screening behaviors. The current study examined perspectives on family interactions around skin cancer prevention and control practices through 1  year after test reporting and counseling among children who received melanoma predispositional genetic testing and their pa...
Source: Journal of Community Genetics - Category: Genetics & Stem Cells Source Type: research
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