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Man's Life Saved When He Gets Heart Still Beating In A Box

Lee Hall got the gift of life -- and it was still beating when it arrived. The 26-year-old Cornwall, U.K. resident was diagnosed with heart failure at age 14. At age 20, he had a mechanical pump installed to keep the blood flowing around his body. But Hall got some bad news in May. Doctors said his heart pump cables were infected, and he'd need a new heart within two days or he would die, according to South West News Service. But Hall got a lucky break when he learned he had a heart donor. The dead patient's heart was revived for Hall, using a method called a "heart in a box" that keeps the organ beating outside of the donor's body. First, doctors provided a passage of warm blood through the donated heart. The blood was heated to reduce tissue damage and oxygenated using a gas exchanger right up until the moment it was transplanted into Hall's body. The method can keep a heart alive for up to eight hours. Hall underwent the procedure earlier this summer. He's back home with wife, Danyelle, and their one-year-old son, Hayden.  "The fact that they could keep that heart alive in the box was the difference between life and death for me," Hall told South West News Service. "I just woke up feeling so much better than I ever had. It has made a huge difference." The "heart in a box" technology was designed by Transmedics, a medical technology company based in Andover, Massachusetts. The company also makes similar products for li...
Source: Science - The Huffington Post - Category: Science Source Type: news

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In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Heart failure with reduced ejection fraction (HFrEF) following orthotopic liver transplantation (OLT) is a poorly understood phenomenon, reported in 3 to 7% of transplanted patients. The purpose of this study was to identify risk factors that may predict HFrEF following OLT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Multiorgan dysfunction syndrome (MOD) contributes to adverse outcomes in advanced heart failure (AdHF) patients after mechanical circulatory support (MCS) implantation and is associated with aberrant leukocyte activity. We tested the hypothesis that preoperative peripheral blood mononuclear cell (PBMC) gene expression profiles (GEP) are associated with early postoperative improvement/non-improvement of Sequential Organ Failure Assessment (SOFA) score and Model of Endstage Liver Disease Except INR (MELD-XI) score as surrogate markers for 1-year survival in patients undergoing MCS implantation and that this information might...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Multiorgan dysfunction syndrome (MOD) contributes to adverse outcomes in advanced heart failure (AdHF) patients after mechanical circulatory support (MCS) implantation and is associated with aberrant leukocyte activity. We tested the hypothesis that early postoperative improvement/non-improvement of Sequential Organ Failure Assessment (SOFA) score and Model of Endstage Liver Disease Except INR (MELD-XI) score, termed Functional Recovery (FR) Score, serves as surrogate markers for 1-year survival in patients undergoing MCS-surgery.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
By ANISH KOKA, MD No one knows who Bennie Solis is anymore. He had the misfortune of being born in the early 1960s marked for death. He had a rare peculiar condition called biliary atresia – a disease defined by the absence of a conduit for bile to travel from his liver to his intestinal tract. Bile acid produced in the liver normally travels to the intestines much like water from a spring travels via ever larger channels to eventually empty into the ocean. Bile produced in the liver with no where to go dams up in the liver and starts to destroy it. That the liver is a hardy organ was a fact known to the ancient Gree...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
AbstractPurposeEnd-stage renal disease (ESRD) is associated with increased cardiovascular risk factors, electrolyte imbalances, and iron deficiency anemia. These factors may increase the risk of adverse outcomes in patients undergoing panniculectomy. There is a paucity of data regarding outcomes in patients with ESRD undergoing panniculectomy. The purpose of this study is to investigate whether ESRD is associated with increased rate of complications following a panniculectomy.MethodThe Nationwide Inpatient Sample database (2006 –2011) was used to identify patients who underwent a panniculectomy. Among this cohort, pa...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
In conclusion, evaluation of patient selection for heart transplantation should be comprehensive and individualized with respect to indications and the risk of comorbidities of candidates. With the advancement of mechanical circulatory support (MCS), the selection of heart transplantation candidate is continuously evolving and widened. MCS as bridge to candidacy should be considered when the candidate has potentially reversible risk factors for transplantation.
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Semin Respir Crit Care Med 2017; 38: 651-661 DOI: 10.1055/s-0037-1606251Portal hypertension may have major consequences on the pulmonary vasculature due to complex pathophysiological interactions between liver and lungs. Portopulmonary hypertension (PoPH) is characterized by the association of portal hypertension and pulmonary arterial hypertension (PAH). As progressive elevation of right ventricular afterload can lead to right heart failure, PoPH is a serious complication of portal hypertension, affecting functional status and prognosis of patients. Early detection by transthoracic echocardiography must be performed in sy...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
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