Man's Life Saved When He Gets Heart Still Beating In A Box

Lee Hall got the gift of life -- and it was still beating when it arrived. The 26-year-old Cornwall, U.K. resident was diagnosed with heart failure at age 14. At age 20, he had a mechanical pump installed to keep the blood flowing around his body. But Hall got some bad news in May. Doctors said his heart pump cables were infected, and he'd need a new heart within two days or he would die, according to South West News Service. But Hall got a lucky break when he learned he had a heart donor. The dead patient's heart was revived for Hall, using a method called a "heart in a box" that keeps the organ beating outside of the donor's body. First, doctors provided a passage of warm blood through the donated heart. The blood was heated to reduce tissue damage and oxygenated using a gas exchanger right up until the moment it was transplanted into Hall's body. The method can keep a heart alive for up to eight hours. Hall underwent the procedure earlier this summer. He's back home with wife, Danyelle, and their one-year-old son, Hayden.  "The fact that they could keep that heart alive in the box was the difference between life and death for me," Hall told South West News Service. "I just woke up feeling so much better than I ever had. It has made a huge difference." The "heart in a box" technology was designed by Transmedics, a medical technology company based in Andover, Massachusetts. The company also makes similar products for li...
Source: Science - The Huffington Post - Category: Science Source Type: news

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In patients with liver failure who have coexisting heart failure, combined heart-liver transplantation (CHLT) can be performed. Outcomes in terms of survival and freedom from rejection remain largely unknown due to lack of sufficient data. The goal of this study was to pool the existing literature for evaluating outcomes after CHLT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 984 Source Type: research
Right heart failure following left ventricular assist device implantation is one of the major challenges in patients suffering from advanced heart failure. There is still no ideal right-sided support system available. Here we describe the implantation of a stent valve at the inferior cavoatrial junction to protect liver and kidney during right heart failure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 920 Source Type: research
The Model of End-Stage Liver Disease (MELD) score incorporates measures of kidney and liver dysfunction. MELD score has been shown to predict mortality in patients with advanced heart failure or cardiogenic shock (CS). Prior small single-center studies have shown that MELD score predicts mortality in patients supported with Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). The Purpose of our was to reassess the role of MELD score predicting Mortality After (VA-ECMO).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1099 Source Type: research
Previous studies have indicated that the Model for End-stage Liver Disease (MELD) score as a metric for liver congestion and right heart failure predicts survival in patients undergoing left ventricular assist device (LVAD) implantation. The predictive value of the MELD has never been evaluated for predicting postoperative survival for patients implanted with the total artificial heart (TAH), where right heart failure does not exist. The goal was to evaluate the preoperative MELD for predicting survival after TAH.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1119 Source Type: research
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System An Interview with a Programmed Aging Theorist An Interview with Reason at the Life Extension Advocacy Foundation An Interview on Mitochondrial Damage and Dysfunction in Aging An Interview with Vadim Gladyshev on Research into the Causes of Aging An Interview with Jim Mellon, and Update on Juvenescence A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation An Interview with Peter de Keize...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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