Effect of micronized purified flavonoid fraction therapy on endothelin-1 and TNF-α levels in relation to antioxidant enzyme balance in the peripheral blood of women with varicose veins.
Conclusion We demonstrate the ability of MPFF to effectively lower the levels of ET-1 and TNF-α in patients with chronic venous disease. Further investigations are needed to define the therapeutic potential of MPFF including the potential effect on chronic subclinical inflammation, antioxidant imbalance and vascular dysfunction during the development of chronic venous disease.
PMID: 26311575 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Pietrzycka A, Kózka M, Urbanek T, Stępniewski M, Kucharzewski M Tags: Curr Vasc Pharmacol Source Type: research