Mutations in the Kinase Domain of the / Gene Identified in a Wide Variety of Human Cancers

We report mutation analyses of the HER2 kinase domain in 7497 histologically diverse cancers. Forty-five genes, including the kinase domain of HER2 with HER2 IHC and dual in situ hybridization, were analyzed in tumors from 7497 patients with cancer, including 850 breast, 770 colorectal, 910 non–small cell lung, 823 uterine or cervical, 1372 ovarian, and 297 pancreatic cancers, as well as 323 melanomas and 2152 other solid tumors.

Source: Journal of Molecular Diagnostics - August 28, 2015 Category: Pathology Authors: Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan Bender, Anatole Ghazalpour, Zheng Tan, Jeffrey Swensen, Sherri Z. Millis, Gargi Basu, Zoran Gatalica, Michael F. Press Tags: Regular article Source Type: research