Trans-generational effect of maternal obesity on the programming of hypertension: Altered leptin signalling pathway in the central nervous system

The prevalence of obesity in women among child baring age is increasing and this has been parallel to the increase in obesity in general population around the world. We investigated the trans-generational ‘programming’ of leptin signalling in the central nervous system (CNS) to increase blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) following a high fat diet (HFD)feeding in mothers. Female New Zealand White rabbits were fed a high fat (13%) diet (mHFD) or a control diet (mCD) prior mating and during pregnancy.
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Authors: Tags: P9.6 Source Type: research