Structure of RizA, an l-amino-acid ligase from Bacillus subtilis

RizA is an l-amino-acid ligase from Bacillus subtilis that participates in the biosynthesis of rhizocticin, an oligopeptide antibiotic. The substrate-free form of RizA has been crystallized and the structure was solved at 2.8 Å resolution. The amino-acid-binding site appears to be capable of accommodating multiple amino acids, consistent with previous biochemical studies.
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: l-amino-acid ligase ATP-grasp fold rhizocticin dipeptide synthesis research communications Source Type: research
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