Transplantation: Fc-silent anti-CD40 antibody prolongs allograft survival

Nature Reviews Nephrology 11, 504 (2015). doi:10.1038/nrneph.2015.122 Blockade of the CD40–CD154 pathway prolongs renal allograft survival in nonhuman primates, but anti-CD154 antibodies are associated with thromboembolic complications and anti-CD40 antibodies are associated with varying degrees of B-cell depletion. To assess the contribution of B-cell depletion to allograft survival, researchers from Novartis Institutes
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Tags: Research Highlight Source Type: research