Immunology: T-cell exhaustion limits immune reactivity and is associated with good prognosis in autoimmune disease

Nature Reviews Nephrology 11, 503 (2015). doi:10.1038/nrneph.2015.115 Author: Ellen F. Carney A transcriptional signature of CD8 T-cell exhaustion is associated with good prognosis in multiple autoimmune diseases—including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE)—but with poor outcomes in chronic infections, say researchers Eoin McKinney and colleagues. They suggest that measuring this signature could
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research