Should Ondansetron Be Used for Acute Gastroenteritis?

Discussion Acute gastroenteritis (AGE) is a common illness worldwide and is “…defined as a decrease in the consistency of stools (loose or liquid) and/or an increase in the frequency of evacuations with or without fever or vomiting….” It is one of the most common reasons for seeking medical care and hospitalizations. In Europe, rotavirus and noroviruses are two of the most frequent viral agents causing AGE and Campylobacter and Salmonella are the most common bacterial AGE causes. For parasitic infections Giardia, and Crytosporidium are most common parasitic infections in Europe. Recommendations for AGE treatment include oral rehydration, nasogastric rehydration and or intravenous rehydration. The European Society of Pediatric Gastroentrology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases recommends oral and nasogastric rehydration before trying intranveous rehydration. They note that “…oral rehydration is more effective and less invasive than IV rehydration and the administration of [oral rehydration solutions] should be attempted and promoted.” Additionally if IV therapy is used, patients “… should be made to switch or oral rehydration as soon as indication for parental rehydration are no longer observed.” Those indications for IV rehydration include shock, dehydration that is accompanied by a change of consciousness or severe acidosis, worsening dehydration or lack of improvement...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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In this study, we found that the PPL length of Korean SG isolates varied from 11 to 21 prolines and was longer than that of a live vaccine strain, SG 9R (9 prolines). According to growth competition in chickens, the growth of an SG isolate with a PPL length of 17 prolines exceeded that of an SG isolate with a PPL length of 15 prolines. We investigated the pseudogenes of the field isolates, SG 9R and reference strains in GenBank by resequencing and comparative genomics. The pseudogene profiles of the field isolates were notably different from those of the foreign SG strains, and they were subdivided into 7 pseudogene subgro...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 25 May 2019Source: Preventive Veterinary MedicineAuthor(s): Ricardo Lopes, Amanda Brinch Kruse, Liza Rosenbaum Nielsen, Telmo Pina Nunes, Lis AlbanAbstractIn modern livestock farming, there is an increasing understanding that antimicrobial (AM) consumption must be kept low – preferably without compromising animal welfare or productivity. This requires an understanding of the relationship between AM use, productivity, biosecurity, vaccination and herd demographics. To obtain this, we undertook an Additive Bayesian Network analysis using data from 2014-15, covering 157 Danish sow herd...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Conclusion:   CoBaT-Y017 presented a significant safety and tolerability in healthy volunteers to allow its further development by starting a phase II clinical study. PMID: 31118966 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study aimed to investigate the diagnostic value of fractional exhaled nitric oxide (FeNO) combined with small airway functional parameters in cough variant asthma. MATERIAL AND METHODS Children with asthma (n=136) were divided into a cough variant asthma (CVA) group (n=57; mean age, 8.03±2.1 years) and a non-cough variant asthma (nCVA) group (n=79; mean age, 8.61±1.7 years). In both groups, FeNO and other pulmonary function parameters were measured including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), maximum mid-expiratory flow (MMEF), forced e...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
In conclusion, our research provides a candidate vaccine for the prevention of Aeromonas salmonicida A450 infection in rainbow trout and lays the foundation for future research on adaptive immune mechanisms associated with rainbow trout antibodies.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsDovyalis caffra has been tested for various biological activities and the extracts (seeds in particular) demonstrated promising antibacterial potential. A lack of alignment between the ethno-medicinal uses and existing biological screenings was observed, indicting the need for anti-inflammatory and anti-rheumatism potential of Dovyalis caffra to be explored. In vivo validation of antibacterial and anti-parasitic activities against clinical bacterial strains and parasites, respectively is required. Other areas that need investigation are safety evaluations and development of integrated cultivation approach in ord...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Andréa A.S. Mendonça, Reggiani V. Gonçalves, Thaiany G. Souza-Silva, Izabel R.S.C. Maldonado, André Talvani, Antônio J. Natali, Rômulo D. NovaesAbstractWhen administered alone, preinfection exercise training and benznidazole-based chemotherapy induce cardioprotection in Chagas disease. However, the effect of concomitant exercise and benznidazole treatment is unknown. We investigated whether exercise and specific chemotherapy could interact to modulate parasitemia, inflammation, redox status and heart damage...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Casadevall A Abstract The fungal kingdom poses major catastrophic threats to humanity but these are often unappreciated and minimized, in biological threat assessments. The causes for this blind spot are complex and include the remarkable natural resistance of humans to pathogenic fungi, the lack of contagiousness of human fungal diseases, and the indirectness of fungal threats, which are more likely to mediate their destructive effects on crops and ecosystems. A review of historical events reveals that the fungal kingdom includes major threats to humanity through their effects on human health, agriculture...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Authors: Pio L, Boccardo F, Avanzini S, Paraboschi I, Granata C, Garaventa A, Dessalvi S, Martucciello G, Mattioli G Abstract Chylous ascites may complicate the postoperative course of abdominal surgery mainly due to the iatrogenic disruption of the lymphatic channels during extensive retroperitoneal dissection. Sparse data are available regarding treatment; however, in many cases a recommended first-line treatment approach is by way of enteral feeding, consisting of a formula high in medium-chain triglycerides (MCTs) together with a complete total parenteral nutrition teamed with somatostatin (or an equivalent). N...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
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