Why President Carter's Melanoma Announcement Was Groundbreaking

Former President Jimmy Carter announced in a press conference Thursday that cancer has spread to his brain, and that he will be receiving radiation over the next few months to treat it.  With candor that's typical for Carter, but remarkable compared to how other American presidents have announced illnesses, the former president described that he first sought treatment for a bad cold in May. Instead, doctors found a mass on his liver that turned out to be melanoma. Surgeons removed the cancer, as well as about one-tenth of his liver, in an operation August 3, but discovered that the cancer had spread to his brain. These four lesions, measuring about two millimeters, were treated with radiation on August 20 and then again every three weeks. Carter is also receiving a drug that enhances his immune system.  “I’m perfectly at ease with whatever comes,” said Carter. “I do have deep religious faith, which I’m very grateful for, and I was pleasantly surprised that I didn’t go into an attitude of despair or anger or anything like that. I was just completely at ease. “I’m looking forward to a new adventure,” he added.  (function(){var src_url="https://spshared.5min.com/Scripts/PlayerSeed.js?playList=519027675&height=381&width=570&sid=577&origin=SOLR&videoGroupID=155847&relatedNumOfResults=100&responsive=false&relatedMode=2&relatedBottomHeight=60&companionPos=&hasCompanion=false&autoStart=false&colorPallet=%23FFEB...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and aversion. Aversive signaling causes extensive suffering during chronic diseases, including inflammatory conditions, cancer, and depression. Here, we investigated the role of melanocortin 4 receptors (MC4Rs) in aversive processing using genetically modified mice and a behavioral test in which mice avoid an environment that they have learned to associate with aversive stimuli. In normal mice...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression. However, the mechanisms underlying how RTKs drive prostate cancer remain incompletely characterized. Here we show that non-proteolytic ubiquitination of RTK regulates its kinase activity and contributes to RTK-mediated prostate cancer metastasis. TRAF4, an E3 ubiquitin ligase, is highly expressed in metastatic prostate cancer. We demonstrated here that it is a key player in regulating RTK-mediated prostate cancer metastasis. We further i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ01713A, PaperTania Lozano-Cruz, Rafael Gomez, F. Javier de la Mata, Paula Ortega A water soluble "bow-tie" cationic carbosilane dendrimer with curcumin in the core displays antioxidant and antitumoral activities against breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasi...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Plast Surg Source Type: research
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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AbstractImmunosuppression in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is complicated by increasing risk of infections including opportunistic infections like Pneumocystis jirovecii pneumonia (PJP). Available evidence on risk factors and indications for prophylaxis in AAV is derived from PJP occurring early in the course of AAV. In this retrospective study, we characterized the profile of PJP in patients with AAV. PJP cases were identified retrospectively based on positive polymerase chain reaction test from electronic record followed by confirmation from medical records over a 10-year period....
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AbstractTo report our experience in using rituximab (RTX) for treating refractory rapidly progressive interstitial lung disease (RP-ILD) complicating anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab)-positive amyopathic dermatomyositis (ADM). Medical records of four ADM patients with refractory RP-ILD treated with RTX therapy were reviewed retrospectively. All four patients were tested positive for anti-MDA5 Ab and failed to respond to high-dose systemic steroid and other intensive immunosuppressive therapies. Respiratory symptoms, lung function tests, and high-resolution computed tomography (HRCT) of...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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