The cancer therapy breakthrough that gives President Carter hope

Former U.S. President tries to hold off metastatic cancer with an antibody that unleashes the immune system on malignancies
Source: ScienceNOW - Category: Science Source Type: news

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Publication date: Available online 23 May 2019Source: Pharmacology &TherapeuticsAuthor(s): Junko Murai, Anish Thomas, Markku Miettinen, Yuves PommierAbstractSchlafen 11 (SLFN11) sensitizes cells to a broad range of anti-cancer drugs including platinum derivatives (cisplatin and carboplatin), inhibitors of topoisomerases (irinotecan, topotecan, doxorubicin, daunorubicin, mitoxantrone and etoposide), DNA synthesis inhibitors (gemcitabine, cytarabine, hydroxyurea and nucleoside analogues), and poly(ADPribose) polymerase (PARP) inhibitors (olaparib, rucaparib, niraparib and talazoparib). In spite of their different primary...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 May 2019Source: International Journal of PharmaceuticsAuthor(s): Patrícia Cerqueira, Jennifer Noro, Sofia Moura, Diana Guimarães, Carla Silva, Artur Cavaco-Paulo, Ana LoureiroAbstractPolyoxyethanyl-α-tocopheryl sebacate (PTS) is an amphiphilic compound with self-emulsifying properties known to form micelles. In this work, we report the production of PTS micelles for the encapsulation and delivery of a hydrophobic derivative of methotrexate, MTX di-ethylated (MTX-OEt). We optimized the micelles production by testing two different techniques: auxiliary solvent and son...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
In this study, the elucidation of mechanisms underlying the anticancer effects of the apigenin, luteolin and myricetin will be new knowledge about preventive strategies against epithelial ovarian cancer in which the effect of flavonoids is still unclear. The cytotoxic effect of flavonoids was assessed by MTT analysis of the ovarian cancer cells (A2780, OVCAR-3 and SKOV-3) in comparison to the ovarian epithelial cells (OSE). The intracellular reactive oxygen species (ROS) generation, malondialdehyde (MDA) and protein carbonyl levels, caspase-3 and -9 activities were evaluated using fluorescence spectrometry. Apoptosis and c...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Yang Z, Sun Z, Ren Y, Chen X, Zhang W, Zhu X, Mao Z, Shen J, Nie S Abstract Nanomaterials play crucial roles in the diagnosis and treatment of diseases. Photothermal and photodynamic therapy, as two minimally invasive therapeutic methods, have promising potential in the diagnosis and prevention of cancer. Recently, many photothermal materials (such as noble metal material, transition metal sulfur oxides, carbon material and upconversion nanomaterial) and photodynamic materials (such as phthalein cyanogen, porphyrins and other dye molecules) have been applied in photothermal therapy (PTT) and photodynamic t...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: September 2019Source: Materials Science in Semiconductor Processing, Volume 100Author(s): Lakshmi Kalyani Ruddaraju, Panduranga Naga Vijay Kumar Pallela, S.V.N. Pammi, Veerabhadra Swamy Padavala, Venkata Ramana Murthy KolapalliAbstractThe present investigation deals with the antibiotic potentiation and antitumor activity of green processed Ag NPs. Silver nanoparticles were prepared using Annona squamosa (AS) leaf extract as a potent bio-reducer and stabilizer. An intense surface plasmon resonance (SPR) band around 430 nm indicates the formation of well-stabilized silver nano particles, which was conform...
Source: Materials Science in Semiconductor Processing - Category: Materials Science Source Type: research
Authors: Qing L, Qing W Abstract PMID: 31115241 [PubMed - as supplied by publisher]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 13, Part 2Author(s): Nareg Ohannesian, Carlos Trevino De Leo, Karen S. MartirosyanAbstractDextran coated biocompatible water-based magnetite (Fe3O4) nanostructured media was produced via microfluidic process at various flow rates. The influences of dextran molecular weight on the magnetite particle size and magnetic property of nano fluid were investigated. Magnetite produced at flow rate of 0.04 mL/s showed uniform particle size distribution with average size 10 nm and saturation magnetization (Ms) up to 60 emu/g. The X-ray diffraction pattern indicates pu...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 13, Part 2Author(s): Javier Donoso-Quezada, Daniel Guajardo-Flores, José González-ValdézAbstractExosomes are membrane-derived nanovesicles secreted by a variety of cell types to the extracellular space for intercellular communication. Based on this biological function, exosomes have been used in numerous applications such as drug delivery. In this work, exosomes isolated from MCF7, Caco2, PC3 and HepG2 cell lines were characterized and loaded with bioactive compounds from black bean extract by electroporation. The cellular uptake and th...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
ConclusionsGood agreement with a large set of experimental data on clonogenic cell survival, inactivation cross section, and RBE emphasizes the predictive power of the MSA. In the high-LET regime, the fact that a given number of ions may produce more damage than needed for a given biological effect leads to a significant (up to 20%) variation in RBE. Consideration of this effect in the analysis of experimental data on irradiation with high-LET ions may lead to re-evaluation of RBE in this regime.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research
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