Vitamin C promotes wound healing through novel pleiotropic mechanisms

In conclusion, VitC favorably on proliferation. Histological analysis showed improved wound matrix deposition and organisation in sufficient and deficient +AscA mice. Wounds from VitC sufficient and deficient + AscA mice had reduced expression of pro‐inflammatory mediators and higher expression of wound healing mediators. Supplementation of HnDF with AscA induced the expression of self‐renewal genes and promoted fibroblast proliferation. VitC favourably impacts the spatiotemporal expression of transcripts associated with early resolution of inflammation and tissue remodelling.

Source: International Wound Journal - August 20, 2015 Category: Surgery Authors: Bassem M Mohammed, Bernard J Fisher, Donatas Kraskauskas, Susan Ward, Jennifer S Wayne, Donald F Brophy, Alpha A Fowler, Dorne R Yager, Ramesh Natarajan Tags: ORIGINAL ARTICLE Source Type: research