Obesity-Cancer Link in Lynch Syndrome Quashed by AspirinObesity-Cancer Link in Lynch Syndrome Quashed by Aspirin

Obese individuals with Lynch syndrome have an increased risk for colorectal cancer that appears to be eliminated by regular aspirin. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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AbstractLifestyle factors related to energy balance, such as excess body weight, poor diet, and physical inactivity, are associated with risk of sporadic endometrial cancer (EC) and colorectal cancer (CRC). There are limited data on energy balance-related lifestyle factors and EC or CRC risk among individuals with lynch syndrome, who are at extraordinarily higher risk of developing EC or CRC. We conducted a systematic review of evidence related to weight status, weight change, dietary habits, and physical activity on EC and CRC risk among individuals with lynch syndrome. Findings are reported narratively. We searched Medli...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
Consumer genetics company 23andMe is diving deeper into the medical space. On Jan. 22, the company announced that the Food and Drug Administration (FDA) approved its newest report, which can flag whether people have genetic variants that may raise their risk of developing colorectal cancer. The new test looks for two gene variants associated with MUTYH-associated polyposis, an inherited colorectal cancer syndrome. “If left unchecked, carrying both of these variants or having two copies of one increases the risk of developing colorectal cancer to between 43 and 100 percent,” according to 23andMe. The test will b...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news
Genetic factors play an important role in shaping the biologic characteristics of malignant tumors, especially in young patients. We aimed to determine the clinicopathologic features of endometrial cancer (EC) in patients younger than 50 years with a family history of cancer. Overall, 229 patients with EC, including 40 with a positive family history of cancer (PFH) and 189 with a negative family history of cancer (NFH), were enrolled in this case–control study. The family history of cancer in a 2-generation pedigree was recorded for the PFH group. Clinicopathologic features such as menarche age, body mass index, per...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
CRC is one of the major public health problems worldwide representing the third most common cancer in men and the second in women with more than 600,000 deaths every year [1,2]. The emergence of new cases of CRC may be related to various risk factors, including: diet, lifestyle, smoking, hereditary syndromes (familial adenomatous polyposis, Lynch syndrome, and MYH-associated polyposis, etc.), obesity, high alcohol intake, family history, inflammatory bowel disease and age> 50 (Supplemental Figure S1) [3].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
A new study released by the National Cancer Institute shows colon and rectal cancers have increased dramatically and steadily in young and middle-age adults in the United States over the past four decades. Dr. Yixing Jiang, a Medical Oncologist at the University of Maryland Greenebaum Comprehensive Cancer Center, answers all the questions you’re now asking yourself about colon cancer. Q. What are the risk factors for colon cancer? A. The risks for developing colon cancer are: obesity; insulin resistance diabetes, red and processed meat; tobacco; alcohol; family history of colorectal cancer; certain hereditary syndrom...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Cancer Health Tips colon cancer maryland research study treating colon cancer Source Type: blogs
Chemoprevention offers an attractive option to prevent the occurrence of cancer in high risk cancer syndromes, such as familial adenomatous polyposis (FAP) and Lynch syndrome. However, data, especially from clinical trials, is sparse. This presentation will review the state of art concepts of chemoprevention in regards to these hereditary GI cancer syndromes.Lynch Syndrome: In the randomized CAPP2 trial, 861 participants with Lynch syndrome took either daily aspirin (600 mg) or placebo for up to 4 years; the primary endpoint was the development of CRC (1). After a mean follow-up of 55.7 months, participants taking daily as...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Prevention Source Type: research
March is Colon Cancer Awareness Month, today’s TBT post provides some helpful information on colorectal cancer. Michelle was a healthy, active 47 year old. She tried to eat right and she exercised. It looked like the hard work was paying off: no health issues and lots of energy. Her work in the healthcare field motivated her to see her doctors regularly for checkups, to get mammograms and to have her blood work done annually. She knew she was getting close to the magical age of 50 and that soon she would need to get a colonoscopy to screen for colorectal cancer.  Since she had no family history of the disease sh...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Cancer TBT Source Type: blogs
By Stacy Simon Colon cancer is one of the more common cancers in the US. About 1 in 20 Americans will develop colon cancer at some point during their lifetime. But there are things you can do to help lower your colon cancer risk. Here are 6 ways to help protect your colon health. Get screened for colon cancer. Screenings are tests that look for cancer before signs and symptoms develop. Colon screenings can often find growths called polyps that can be removed before they turn into cancer. These tests also can find colon cancer earlier, when treatments are more likely to be successful. The American Cancer Society recommend...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Colon/Rectum Cancer Source Type: news
Conclusion Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Epidemiology Gastrointestinal Cancer Source Type: research
Nature Reviews Clinical Oncology 12, 562 (2015). doi:10.1038/nrclinonc.2015.148 Whether adiposity is a risk factor for the development of hereditary colorectal cancer (CRC) in patients with Lynch syndrome is unclear. In a prospective study, 937 patients were randomly assigned to receive daily aspirin (600 mg) or placebo. The CRC risk was greater in obese
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Tags: Research Highlight Source Type: research
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