Annals of Neurology: Volume 78, Number 3, September 2015

ON THE COVER: Blue staining representing expression of Fat1 on cross‐section at shoulder level of a mouse embryo at 14.5 days of development. The blue stain is due to a color reaction for β‐galactosidase due to the LacZ gene being inserted in the Fat1 locus, under the control of Fat1 regulatory elements. Different muscle groups located in the shoulder and forearm area are stained blue. Most of the muscles known to be affected at early stages of FacioScapuloHumeral Dystrophy (FSHD) in humans exhibit low levels of Fat1 expression in mice, supporting the correlation between low FAT1 expression levels and muscles affected early in FSHD. For more information, see the article by Mariot et al. (pages 387–400).
Source: Annals of Neurology - Category: Neurology Tags: Cover Image Source Type: research