Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators.

Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators.
J Inorg Biochem. 2015 Aug 11;
Authors: Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-Pelaez MG, Ostrowska M, Jezierska J, Gumienna-Kontecka E, Peana M, Zoroddu MA, Choquesillo-Lazarte D, Niclós-Gutiérrez J, González-Pérez JM
Abstract
High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed with essential metal ions, in order that these last ones do not perturb iron chelation. In the frame of our research on iron chelators we have designed and synthesized a series of tetradentate derivatives of kojic acid, and examined their binding properties toward Fe(3+) and Al(3+). In this paper, for a characterization of the behavior of the proposed iron chelating agents in biological fluids, their complex formation equilibria with copper(II) and zinc(II) ions have been fully characterized together with a speciation study, showing the degree at which the iron chelators interfere with the homeostatic equilibria of these two essential metal ions.
PMID: 26281974 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - August 11, 2015 Category: Biochemistry Authors: Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-Pelaez MG, Ostrowska M, Jezierska J, Gumienna-Kontecka E, Peana M, Zoroddu MA, Choquesillo-Lazarte D, Niclós-Gutiérrez J, González-Pérez JM Tags: J Inorg Biochem Source Type: research