Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease

Publication date: Available online 14 July 2015 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Paul Cathcart, Walter Lucchesi, Silvia Ottaviani, Alex De Giorgio, Jonathan Krell, Justin Stebbing, Leandro Castellano Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research