World Health Organization: Expanding Efforts and Strategies to Prevent and Control TB Including Multidrug-Resistant TB, and TB in Vulnerable Populations

Funding Opportunity Number: CDC-RFA-PS14-141202CONT16 Opportunity Category: ContinuationFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.116Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-CDCClosing Date: Aug 25, 2015Award Ceiling: $0Expected Number of Awards: 50Creation Date: Aug 19, 2015Funding Opportunity Description: World Health Organization: Expanding Efforts and Strategies to Prevent and Control TB Including Multidrug-Resistant TB, and TB in Vulnerable Populations
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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AbstractThe increasing prevalence of multidrug-resistant strains ofMycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the treatment of this plight. In search for such drugs, we investigated a series of benzyltriazole derivatives. We herein report the design, synthesis and biological activity of disubstituted benzyltriazoles against the human virulent H37Rv strain ofMtb as well as the toxicity on human embryonic kidney (HEK-293) cells. The derivative21 featuring trifluoromethyl substituent inpara position on the phenyl r...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
ConclusionsTherapeutic drug monitoring-guided meropenem may be a sound new therapeutic option in eradicating multidrug resistant Acinetobacter and offer a novel therapeutic option in the field of personalized medicine.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Tuberculosis (TB) has now surpassed HIV as the leading infectious cause of death, and treatment success rates are declining. Multidrug-resistant TB, extensively drug-resistant TB, and even totally drug-resistant TB threaten to further destabilize disease control efforts. The second wave in TB drug development, which includes the diarylquinoline, bedaquiline, and the nitroimidazoles delamanid and pretomanid, may offer options for simpler, shorter, and potentially all-oral regimens to treat drug-resistant TB. The “third wave” of TB drug development includes numerous promising compounds, including less toxic versi...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
Vancomycin-resistant enterococci are troublesome pathogens in clinical settings because of few treatment options. A VanA/VanM-type vancomycin-resistant Enterococcus faecium clinical isolate was identified in Japan. This strain, named AA708, harbored five plasmids, one of which migrated during agarose gel electrophoresis without S1 nuclease treatment, which is indicative of a linear topology. We named this plasmid pELF1. Whole genome sequencing (WGS) analysis of the AA708 strain revealed that the complete sequence of pELF1 was 143,316 bp long and harbored both the vanA and vanM gene clusters. Furthermore, mfold analysis and...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractThe aim was to develop a predictive model of infection by multidrug-resistant microorganisms (MDRO). A national, retrospective cohort study was carried out including all patients attended for an infectious disease in 54 Spanish Emergency Departments (ED), in whom a microbiological isolation was available from a culture obtained during their attention in the ED. A MDRO infection prediction model was created in a derivation cohort using backward logistic regression. Those variables significant atp 21 points). Findings were similar in the validation cohort. Several patient-specific factors were independently associate...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
ConclusionsWe found a low level of MDRO awareness and knowledge of associated control measures among French HCWs. Training on hand hygiene and measures to control MDRO spread may be helpful in shaping beliefs and perceptions on MDRO control among other possible associated factors. Messages should be tailored to professional status and their perception. Other approaches should be designed, with more effective methods of training and cognitive interventions.Trial registrationClinical Trials.govNCT02265471. Registered 16 October 2014 - Retrospectively registered.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b17086
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
Authors: Del Puente F, Giacobbe DR, Salsano A, Maraolo AE, Ong DSY, Yusuf E, Tutino S, Marchese A, Santini F, Viscoli C Abstract Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) is a difficult-to-treat pathogen due to its multidrug-resistant phenotype. Cardiac surgery patients are at increased risk of developing KPC-KP infections compared to other populations, with previous KPC-KP colonization being a critical factor in influencing the risk of subsequent infection. Two different pieces of information are essential to comprehensively assess the local characteristics of KPC-KP colonization...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
This study aimed to target adeB gene with antisense peptide nucleic acid (PNA) and investigate its effect on resistance to antibiotics. NCBI database was used to design appropriate PNA to target adeB gene, by connecting PNA to mRNA, the translation of mRNA can be prevented. Three clinical isolates and A. baumannii ATCC 17978 were treated with the designed PNA by electroporation and competence procedure. Minimum Inhibitory concentration (MIC) of ciprofloxacin, colistin, and tetracycline were determined by microbroth dilution method. In addition, the expression level of adeB gene was measured by quantitative real-time PCR (q...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 9 November 2019Source: Microbial PathogenesisAuthor(s): Mahboube Bahroudi, Bita Bakhshi, Sara Soudi, Shahin Najar-peerayehAbstractThe ability of V. cholerae to survive and spread in the aquatic environment combined with the scarcity of effective antimicrobial agents, especially those effective against multidrug-resistant strains highlights the need for alternative non-antibiotic approaches for the treatment of V. cholerae infections. The aim of this study was to specifically examine the potential direct effect of unstimulated MSC secretome on V. cholerae killing and biofilm formation as a...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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