Epithelial Cell Permeability and Drug Absorbtion 1999

Guest Editor(s) Gordon L. Amidon No evidence for the involvement of the multidrug resistance associated protein and or the monocarboxylic acid transporter in the intestinal transport of fluvastatin in rats Author(s) Anders Lindahl Sofia Frid Anna Lena Ungell Hans
Source: AAPS Publications - Category: Drugs & Pharmacology Source Type: news

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Publication date: Available online 18 May 2019Source: PeptidesAuthor(s): Allison B. Reiss, Daniel S. Glass, Eric Lam, Amy D. Glass, Joshua De Leon, Lora J. KasselmanAbstractCardiovascular disease (CVD) remains the leading cause of death worldwide, despite multiple treatment options. In addition to elevated lipid levels, oxidative stress and inflammation are key factors driving atherogenesis and CVD. New strategies are required to mitigate risk and most urgently for statin-intolerant patients. The neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a CVD ancillary treatment be...
Source: Peptides - Category: Biochemistry Source Type: research
In conclusion, PBPK modeling of CP ‐I supports dynamic prediction of OATP1B‐mediated DDIs.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Article Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Anna Palko-Łabuz, Kamila Środa-Pomianek, Olga Wesołowska, Edyta Kostrzewa-Susłow, Anna Uryga, Krystyna MichalakAbstractThe resistance of cancer cells to a variety of structurally non-related cytotoxic drugs is known as multidrug resistance phenomenon (MDR). In cellular membranes an activity of MDR transporters such as P-glycoprotein (ABCB1) is affected by their lipid environment. Many various compounds have been examined for their ability to restore drug-sensitivity of resistant cancer cells. Statins, inhibitors of the key enzy...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, D-PREX with sequential sampling of supernatants prior to cell lysis enables the evaluation of total drug disposition profiles resulting from complex interplays of intracellular pathways, which would provide high-throughput evaluation of drug disposition during drug discovery. PMID: 29724614 [PubMed - as supplied by publisher]
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Abstract As a widely used lipid lowering agent, simvastatin recently has been frequently detected in aquatic environment and the potential adverse effects from simvastatin exposure to non-target organisms such as fish is worthy of more attention. The aim of this study was to reveal the responses of detoxification system in fish to simvastatin exposure. In this investigation a ubiquitous small freshwater fish, mosquito fish (Gambusia affinis), was employed as test organism, and the transcriptional expression of nucleus transcriptional factor pregnane X receptor (PXR) and its downstream genes, including P-glycoprote...
Source: Ecotoxicology and Environmental Safety - Category: Environmental Health Authors: Tags: Ecotoxicol Environ Saf Source Type: research
za DG Abstract The clinical pathogen Klebsiella pneumoniae is a relevant cause of nosocomial infections and resistance to current treatment with carbapenem antibiotics is becoming a significant problem. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) used for controlling plasma cholesterol levels. There is clinical evidence showing other effects of statins, including decrease of lung inflammation. In the current study, we show that pretreatment with atorvastatin markedly attenuated lung injury, which was correlated with a reduction in the cellular influx into the alveolar space and lungs ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Publication date: Available online 2 November 2017 Source:Cell Author(s): Esther García-Fernández, Gudrun Koch, Rabea M. Wagner, Agnes Fekete, Stephanie T. Stengel, Johannes Schneider, Benjamin Mielich-Süss, Sebastian Geibel, Sebastian M. Markert, Christian Stigloher, Daniel Lopez A number of bacterial cell processes are confined functional membrane microdomains (FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells. How bacteria organize these intricate platforms and what their biological significance is remain important questions. Using the pathogen methicillin-resistant Stap...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 23 February 2017 Source:Cell Author(s): Zachary Lee Johnson, Jue Chen The multidrug resistance protein MRP1 is an ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a role in the disposition and efficacy of several opiates, antidepressants, statins, and antibiotics. In addition, MRP1 regulates redox homeostasis, inflammation, and hormone secretion. Using electron cryomicroscopy, we determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 Å without any added substrate and a complex form at 3.3&nbs...
Source: Cell - Category: Cytology Source Type: research
The potential role of non-antibiotic medicinal products in the treatment of multidrug-resistant Gram-negative bacteria has recently been investigated. It is highly likely that the presence of efflux pumps may be one of the reasons for the weak activity of non-antibiotics, as in the case of some non-steroidal anti-inflammatory drugs (NSAIDs), against Gram-negative rods. The activity of eight drugs of potential non-antibiotic activity, active substance standards, and relevant medicinal products were analysed with and without of efflux pump inhibitors against 180 strains of five Gram-negative rod species by minimum inhibitory...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsIn vitro DDI followed by a predictive or PBPK approach was applied to determine DDI potential of canagliflozin. Overall, canagliflozin is neither a perpetrator nor a victim of clinically important interactions.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUG INTERACTIONS Source Type: research
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