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Aspirin lowers risk of hereditary bowel cancer in obese people

ConclusionThis study followed up on a previous trial that found taking aspirin regularly reduced the risk of bowel cancer in people with the genetic condition Lynch syndrome (or HNPCC), which puts them at an increased risk of developing the disease. The study found being obese appears to further increase bowel cancer risk among people with this condition.It also found that BMI did not appear to have an effect on bowel cancer risk among those taking aspirin. While this might indicate that aspirin removes the effect of BMI, ideally a comparison of aspirin versus placebo in the different BMI groups is needed to further assess this. It is likely that the number of people in this trial who fell into the individual BMI categories was not large enough to show an effect.However, this trial may not be representative of what would happen if obese members of the general public took aspirin regularly. The people in this trial were at high risk of bowel cancer because of their condition, and obesity appeared to increase this risk further. Even if taking aspirin can reduce risk in the general public, people may not gain the same benefit as those with Lynch syndrome, and the potential risks associated with aspirin – such as an increased risk of gastrointestinal bleeding – may outweigh any benefits.We know that being overweight or obese has been linked to an increased risk of bowel cancer and also carries other health risks. Aiming to achieve or maintain a healthy body weigh...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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Conclusion: EX-PRESS filtration device has a good IOP-lowering effect and a low rate of complications in patients with advanced NVG associated with PDR. In addition, there was no loss of light perception or no line decrease of the BCVA.Case Rep Ophthalmol 2018;9:61 –69
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
ConclusionOptimal timing of ACS treatment varied significantly based on the clinical indication. Women with preterm prelabour rupture of membranes or vaginal bleeding were more likely to have an ACS‐delivery interval>7 days. A prolonged ACS‐delivery interval was associated with an increased risk of neonatal respiratory morbidity and a prolonged stay in the neonatal care unit, but not with neonatal mortality.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
Conclusion: Risk factors and a more advanced clinical stage of USCC have an impact on poor outcomes despite the use of standard treatment methods, adapted for cervical cancer. The outside-pelvic failures tend to seek effective systemic treatment.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
BOSTON (CBS) – It’s a parent’s worst nightmare, hearing not only that your child has cancer but that she might also lose her eye. That’s exactly what happened to an Andover family and their 3-year-old daughter. But as Dr. Mallika Marshall reports, doctors at Boston Children’s Hospital are using a revolutionary technique to try to save her vision and her life. A little over a year ago Dania Snyder was a typical toddler until her parents noticed something unusual about her right eye. “You could see a little flash of a fleshy piece sort of through her pupil,” explains PJ, Dania’...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Boston Children's Hospital Cancer Dr. Mallika Marshall Source Type: news
KNOXVILLE, Tenn. - A couple on Dec. 11 filed a complaint in Tennessee federal court seeking damages against Monsanto Co., alleging that it knew that the chemical glyphosate, which is the active ingredient in the herbicide Roundup, could pose "significant risks to human health, including a risk of cancer" yet misrepresented it as safe (Warren Ahrent, et al. v. Monsanto Company, No. 18-65, E.D. Tenn.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Wednesday Afternoon Lecture Series Published and unpublished studies by investigators in the pharmaceutical industry indicate that a disturbingly high number of academic laboratories' reports nominating potential new cancer-drug targets are either non-reproducible or, if reproducible, are not sufficiently robust to form the basis for drug-discovery efforts. The reasons are likely multifactorial, including the ubiquitous use of " down " assays in cancer biology (e.g. decreased cell proliferation, decreased tumor growth, etc.) that incorporate chemical and genetic perturbants that are prone to cause off-target effe...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
I thank Maia et  al1 for their interest in our recent article entitled “Outcomes and Role of Urgent Endoscopy in High-Risk Patients With Acute Nonvariceal Upper Gastrointestinal Bleeding.”2
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conclusions:Children with EA are exposed to significant amounts of radiation and an increased estimated cumulative cancer mortality risk. Efforts should be made to eliminate superfluous imaging. Objectives: Cases of esophageal carcinoma have been documented in survivors of esophageal atresia (EA). Children with EA undergo considerable amounts of diagnostic imaging and consequent radiation exposure potentially increasing their lifetime cancer mortality risk. This study evaluates the radiological procedures performed on patients with EA and estimates their cumulative radiation exposure and attributable lifetime cancer mo...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
ABSTRACTObjective:Helicobacter pylori infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H pylori infection and the outcome of H pylori-related gastric cancer. Not all H pylori-infected patients, however, exhibit iron deficiency (ID). The relationship between host genetic polymorphisms and ID mediated by H pylori infection is not well understood.Methods:Subjects (n = 644) from the general population of age 10 to 18 years were divided into 2 groups based on serology testing for anti-H pylori IgG: seropositive study group; and seronegative contr...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
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