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Aspirin lowers risk of hereditary bowel cancer in obese people

ConclusionThis study followed up on a previous trial that found taking aspirin regularly reduced the risk of bowel cancer in people with the genetic condition Lynch syndrome (or HNPCC), which puts them at an increased risk of developing the disease. The study found being obese appears to further increase bowel cancer risk among people with this condition.It also found that BMI did not appear to have an effect on bowel cancer risk among those taking aspirin. While this might indicate that aspirin removes the effect of BMI, ideally a comparison of aspirin versus placebo in the different BMI groups is needed to further assess this. It is likely that the number of people in this trial who fell into the individual BMI categories was not large enough to show an effect.However, this trial may not be representative of what would happen if obese members of the general public took aspirin regularly. The people in this trial were at high risk of bowel cancer because of their condition, and obesity appeared to increase this risk further. Even if taking aspirin can reduce risk in the general public, people may not gain the same benefit as those with Lynch syndrome, and the potential risks associated with aspirin – such as an increased risk of gastrointestinal bleeding – may outweigh any benefits.We know that being overweight or obese has been linked to an increased risk of bowel cancer and also carries other health risks. Aiming to achieve or maintain a healthy body weigh...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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People who undergo root canals may soon have a tiny but powerful ally that could prevent infection after treatment.Researchers at theUCLA School of Dentistry and theUCLA Henry Samueli School of Engineering and Applied Science found in a clinical trial that nanodiamonds protected disinfected root canals after the nerve and pulp were removed, thereby improving the likelihood of a full recovery. The findings are a milestone for the use of nanodiamonds in humans.Nanodiamonds are tiny particles made of carbon and are so small that millions of them could fit on the head of a pin. They resemble soccer balls but have facets like a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Abstract: The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interven...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
We report on a patient who developed massive gastrointestinal hemorrhage related to the use of fluoxetine in combination with aspirin and clopidogrel. A 58-year-old man was admitted with a posterior circulation infarct with significant weakness in all four limbs and dysarthria. Aspirin and clopidogrel were started. Fluoxetine was started for pharmacological neurostimulation to promote motor recovery and for low mood. He developed gastrointestinal hemorrhage a week after fluoxetine was started. Fluoxetine was suspended and investigations failed to reveal the source of the bleeding. He was then restarted on fluoxetine along ...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Reports Source Type: research
Participating in a yoga program while undergoing radiation therapy improved physical functioning and mental in NSCLC patients, and improved vitality in caregivers.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Scientists have identified new genetic variants related to breast cancer risk, nearly doubling the …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news
UAB Hospital has received a 2017 Women ’s Choice Award for being one of America’s Best Breast Centers in the United States. The designation was given to UAB based on clinical excellence and patient satisfaction.  “We take great pride in receiving this honor, especially since it comes from the women we have cared for,” said Dr . Helen Krontiras, director of the UAB Division of Surgical Oncology and medical director of the UAB Breast Health Center. “We now know that breast cancer is not…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Contributors: Ovarian Cancer and Prevention: PDF Only Source Type: research
No abstract available
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
Ovarian carcinomas were formerly referred to as “surface epithelial carcinomas,” reflecting the belief that they all arise from the ovarian surface epithelium. It is now appreciated that most ovarian carcinomas originate from either fallopian tube or endometriotic epithelium, and how we approach prevention will thus differ between histotypes. The 5 histotypes of ovarian carcinoma (high-grade serous, clear cell, endometrioid, mucinous, and low-grade serous, in descending order of frequency) can be reproducibly diagnosed, and are distinct disease entities, differing with respect to genetic risk factors, molecular...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of “ovarian” high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled wi...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
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