MRI scans can deliver cancer therapy

A hospital scan normally used to detect cancer could be used to steer tumour killing treatments to hard-to-reach targets in the body, say scientists.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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In conclusion, we visualized that the synthesized DTX-nanomicelles can be used as an anticancer drug delivery system considering their useful biocompatibility and excellent physicochemical properties.Graphical abstract
Source: European Polymer Journal - Category: Chemistry Source Type: research
AbstractPurpose of ReviewLung cancer is increasingly a disease of the elderly. Historically, the information on how best to treat these patients is scant, but over recent years, there have been increasing data to support both systemic and targeted treatment as would be offered to younger patients. This paper aims to summarise the considerations behind this.Recent FindingsThe introduction of a screening tool to help understand the overall health of patients will ensure that older cancer patients are considered for all active anti-cancer therapies. These geriatric assessment tools include several important domains such as nu...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
PET scans with the radiotracer F-18 fluorothymidine (FLT) can help determine...Read more on AuntMinnie.comRelated Reading: SNMMI: PET, MRI may predict pediatric brain tumor outcomes FDG-PET/CT beats FLT-PET/CT for differentiated thyroid cancer FLT-PET could help predict outcome in head and neck cancer JNM: FLT-PET aids prognosis of glioma patients FLT-PET helps predicts cancer therapy results
Source: Headlines - Category: Radiology Source Type: news
Publication date: Available online 23 July 2018Source: International Journal of PharmaceuticsAuthor(s): Mona Alibolandi, Fazileh Hoseini, Marzieh Mohammadi, Pouria Ramezani, Elham Einafshar, Seyed Mohammad Taghdisi, Mohammad Ramezani, Khalil AbnousAbstractGold NPs have great potential in biomedical applications. PAMAM dendrimers are spherical, hyper branched macromolecules which can encapsulate therapeutic molecules while stabilizing metal nanoparticle such as gold NPs. The aim of the current study was to investigate the theranostic capability of curcumin-loaded dendrimer-gold hybrid structure.Dendrimer-gold hybrid structu...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Authors: Kuljittichanok D, Diskul-Na-Ayudthaya P, Weeraphan C, Chokchaichamnankit D, Chiablaem K, Lirdprapamongkol K, Svasti J, Srisomsap C Abstract The incidence rate of hepatocellular carcinoma (HCC) remains high in numerous countries, including Thailand. There are numerous different lines of HCC treatment; however, various side effects and the resistance of cancer cells during treatment remain issues. At present, traditionally used herb plants have been widely used as alternatives to cancer therapy. Derris scandens is a Thai traditional herb which is commonly found in Thailand and widely used as a traditional me...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Abstract Commonly, acquired resistances to anticancer drug are mediated by overexpression of a membrane-associated protein that encode via multi-drug resistance gene-1 (MDR1). Herein, the mRNA-cleaving DNAzyme that targets the mRNA of MDR1 gene in doxorubicin-resistant breast cancer cell line (MCF-7/DR) loaded on the chitosan β-cyclodextrin complexes was used as a tropical agent. Chitosan/β-cyclodextrin complexes were used to deliver DNAzymes into cancer cells. Determination of the physicochemical characteristics of the particles was done by photon correlation spectroscopy and scanning electron microscop...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Tags: Appl Biochem Biotechnol Source Type: research
Publication date: Available online 7 July 2018Source: Journal of Molecular LiquidsAuthor(s): Samira Malekmohammadi, Hassan Hadadzadeh, Zahra AmirghofranAbstractThe purpose of this study is to develop a targeted drug delivery system containing folic acid-conjugated dendritic amino mesoporous silica nanoparticles (DFMSNs) loaded with a cyclometallated gold(III) complex, [Au(bzpy)Cl2] (bzpy = 2-benzylpyridine), as a cytotoxic agent (Au(drug)@DFMSNs). The products, including the Au(III) complex, DFMSNs, and Au(drug)@DFMSNs, were characterized by transmission electron microscopy (TEM), field-emission scanning electron micro...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: 1 November 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 171Author(s): Rezaei Farnaz, Saeidifar Maryam, Javaheri Masoumeh, Sangpour ParvanehAbstractA novel sustained release carrier of graphene oxide nanosheets functionalized by human serum albumin nanoparticles (FGO-NSs) was synthesized and characterized by field emission scanning electron microscopy (FESEM), zeta sizer analysis, absorption spectroscopy (UV–vis) and Fourier transform infrared spectroscopy (FTIR) studies. The cell viability of GO-NSs, HSA-NPs and FGO-NSs has been tested against human foreskin fibroblast normal cell line...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
This study demonstrated that CPIO carrier could provide a rational design of a stimuli-responsive polymeric prodrug for delivery of irinotecan.Graphical abstractTherapeutic unimolecular micelles extended form β-cyclodextrin conjugated star-like polymer for reductive agent-triggered drug release of irinotecan.
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): M. Gorgizadeh, N. Azarpira, N. SattarahmadyAbstractNanothechnology-mediated photothermal therapy (PTT) is emerging as one of the inspiring alternative modality of cancer therapy that applies near-infrared radiation. High favorability of this approach is due to its minimum invasiveness, safety of non-targeted area, quick recovery, and capable simultaneous imaging. In this approach, photoabsorbing nanomaterials convert energy of infrared light to vibrational motion and generate heat. In the present study, a nanocomposite comp...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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