Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency
Conclusion
Compared with SHAM, remodelled CAL hearts are more tolerant to ischaemic injury and undergo no further deterioration of metabolic efficiency during reperfusion. Less glycogen utilization in CAL hearts during ischaemia may contribute to increased ischaemic tolerance by limiting ischaemic proton production that may improve ion homeostasis during early reperfusion.
Source: Cardiovascular Research - Category: Cardiology Authors: Masoud, W. G. T., Abo Al-Rob, O., Yang, Y., Lopaschuk, G. D., Clanachan, A. S. Tags: Cardiac biology and remodelling Source Type: research
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