Modulation of cardiac fibrosis by Kruppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes
Conclusion
Our present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor, TSP4, which, in turn, modulates activation of cardiac fibroblasts.
Source: Cardiovascular Research - Category: Cardiology Authors: Sawaki, D., Hou, L., Tomida, S., Sun, J., Zhan, H., Aizawa, K., Son, B.-K., Kariya, T., Takimoto, E., Otsu, K., Conway, S. J., Manabe, I., Komuro, I., Friedman, S. L., Nagai, R., Suzuki, T. Tags: Cardiac biology and remodelling Source Type: research